Hemichorea in a thymoma patient without anti-CRMP-5 antibody

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We reported a 72-year-old man with thymoma who presented with hemichorea. Although his brain CT and MRI revealed no abnormality, regional cerebral blood flow changes, identified by single photon emission computed tomography, suggested that the mechanism underlying the chorea seemed to be a dysfunction of the subthalamic nucleus and pallidum. His hemichorea was completely resolved after thymectomy. Absence of serum anti-neural autoantibodies, including small-cell lung carcinoma-related chorea anti-CRMP-5 antibody, suggests that mechanisms different from cross-talk neural-targeted tumor immune response can be responsible for the thymoma-associated paraneoplastic chorea.

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  1. 1.

    Cardoso F (2009) Huntington disease and other choreas. Neurol Clin 27:719–736

  2. 2.

    Cervera R, Asherson RA, Font J, Tikly M, Pallarés L, Chamorro A, Ingelmo M (1997) Chorea in the antiphospholipid syndrome. Clinical, radiologic, and immunologic characteristics of 50 patients from our clinics and the recent literature. Medicine (Baltimore) 76:203–212

  3. 3.

    Yu Z, Kryzer TJ, Griesmann GE, Kim K, Benarroch EE, Lennon VA (2001) CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol 49:146–154

  4. 4.

    Honnorat J, Cartalat-Carel S, Ricard D, Camdessanche JP, Carpentier AF, Rogemond V, Chapuis F, Aguera M, Decullier E, Duchemin AM, Graus F, Antoine JC (2009) Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2/CRMP5 antibodies. J Neurol Neurosurg Psychiatry 80:412–416

  5. 5.

    Takeuchi R, Sengoku T, Matsumura K (2006) Usefulness of fully automated constant ROI analysis software for the brain: 3DSRT and FineSRT. Radiat Med 24:538–544

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We express our gratitude to Professor Keiko Tanaka, Department of Neurology, Kanazawa Medical University, for measurement of neuronal autoantibodies in this case.

Conflict of interest

The authors have no conflict of interest to declare.

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Correspondence to Yoshiharu Nakae.

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Nakae, Y., Ikeda, S., Yamamoto, R. et al. Hemichorea in a thymoma patient without anti-CRMP-5 antibody. Neurol Sci 35, 629–630 (2014) doi:10.1007/s10072-014-1629-4

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  • Paraneoplastic chorea
  • Hemichorea
  • Thymoma
  • Anti-CRMP-5 antibody