Food Science and Biotechnology

, Volume 28, Issue 5, pp 1571–1576 | Cite as

Effect of six Korean plants on glucagon like peptide-1 release

  • Hyunnho Cho
  • Kyong Kim
  • Dae-Ja Jang
  • Hye Young KimEmail author


Glucagon like peptide-1 (GLP-1) plays a major role in the regulation of energy homeostasis as it causes satiety and suppresses appetite. Angelica dahurica, Coreanomecon hylomeconoides, Chrysanthemum morifolium, Portulaca oleracea, Stellaria alsine, and Stellaria media have traditionally been used as famine relief foods in Korea. The aim of the present study was to determine whether the aqueous ethanolic extracts of the six plants stimulate GLP-1 secretion. The results demonstrated that each extract of the plants stimulated GLP-1 secretion from enteroendocrine NCI-H716 cells, respectively. Among the extracts examined, the extract of Portulaca oleracea showed the highest activity on GLP-1 release. The results may suggest that the GLP-1 secretion induced by the six plants is a possible mechanism for the six plants exerting effects on satiety increase and appetite suppression.


Famine relief foods Portulaca oleracea Glucagon like peptide-1 Satiety Enteroendocrine cells 



This research was supported by a Grant from Small Grant for Exploratory Research of Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (Grant No. 2016R1D1A1A02937328), and a Grant from the National Research Council of Science and Technology (Grant Nos. CAP-16-07-KIOM, GN160800-01).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© The Korean Society of Food Science and Technology 2019

Authors and Affiliations

  • Hyunnho Cho
    • 1
  • Kyong Kim
    • 1
  • Dae-Ja Jang
    • 1
  • Hye Young Kim
    • 1
    Email author
  1. 1.Division of Food Function ResearchKorea Food Research InstituteWanju-gunRepublic of Korea

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