Antidiabetic effect of an extract of nutricultured Brassica napus containing vanadium from a Jeju water concentrate
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The purpose of this study was to determine the antidiabetic effect of an extract of nutricultured Brassica napus containing vanadium (BECV). The BECV was prepared following nutriculture of B. napus with a Jeju water vanadium concentrate for 7 day. The BECV was administered to db/db mice for 8 weeks at different dosages (0.028, 0.14, and 0.7 μg/kg; as vanadium concentration in BECV). After 8 weeks, the BECV results showed mouse blood glucose concentrations to significantly decrease, in a dose-dependent manner, compared with the results for control mice. In addition, the concentrations of triglyceride, total cholesterol, and glycated hemoglobin were significantly lower after 8 weeks of administration of 0.7 μg/kg BECV. Therefore, the BECV may have protective effects against type 2 diabetes.
KeywordsVanadium Brassica napus extract Antidiabetic effect db/db mouse
This research was financially supported by the Ministry of Trade, Industry & Energy (MOTIE), Korea Institute for Advancement of Technology (KIAT) and Jeju Institute for Regional Program Evaluation (GWIRPE) through the Leading Industry Development for Economic Region [No. R0000359].
- Brichard SM, Lederer J, Henquin JC. The insulin-like properties of vanadium: A curiosity or a perspective for the treatment of diabetes? Diabete Metab. 17: 435–440 (1991)Google Scholar
- Florkowski C. HbA1c as a diagnostic test for diabetes mellitus-reviewing the evidence. Clin Biochem Rev. 34: 75–83 (2013)Google Scholar
- Ghosh S, Suryawanshi SA. Effect of vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Indian J. Ex. Biol. 39: 748–758 (2001)Google Scholar
- Meyerovitch I, Farfel Z, Sack J, Shechter Y. Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. J. Biol. Chem. 262: 6658–6662 (1987)Google Scholar
- Posner BI, Faure R, Burgess JW, Bevan AP, Lachance D, Zhang-Sun G, Fantus IG, Ng JB, Hall DA, Lum BS, Shaver A. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. J. Biol. Chem. 269: 4596–4604 (1994)Google Scholar
- Ramanadham S, Mongold JJ, Brownsey RW, Cros GH, McNeill JH. Oral vanadyl sulfate in treatment of diabetes mellitus in rats. Am. J. Physiol. 257: H904–H911 (1989)Google Scholar
- Vigneri R, Goldfine, ID. Role of metformin in treatment of diabetes mellitus. Diabetes Care. 10: 118–122 (1987)Google Scholar