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Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

  • Kyungae Jo
  • Hoon Kim
  • Hyeon-Son Choi
  • Seung-Su Lee
  • Myun-Ho Bang
  • Hyung Joo Suh
Article
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Abstract

The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

Keywords

Glyceryl monolinoleate Polygonatum sibiricum Insomnia Sleep GABA type A-benzodiazepine receptor 

Notes

Acknowledgements

This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value-Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (116004-02-2-HD020).

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

References

  1. Abourashed EA, Koetter U, Brattstrom A. In vitro binding experiments with a valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptors. Phytomedicine 11: 633–638 (2004)CrossRefGoogle Scholar
  2. Agosto J, Choi JC, Parisky KM, Stilwell G, Rosbash M, Griffith LC. Modulation of GABA A receptor desensitization uncouples sleep onset and maintenance in Drosophila. Nat. Neurosci. 11: 354–359 (2008)CrossRefGoogle Scholar
  3. Attele AS, Xie JT, Yuan CS. Treatment of insomnia: an alternative approach. Altern. Med. Rev. 5: 249–259 (2000)Google Scholar
  4. Balderer G, Borbely AA. Effect of valerian on human sleep. Psychopharmacology (Berl.) 87: 406–409 (1985)CrossRefGoogle Scholar
  5. Brattstrom A. Scientific evidence for a fixed extract combination (Ze 91019) from valerian and hops traditionally used as a sleep-inducing aid. Wien. Med. Wochenschr. 157: 367–370 (2007)CrossRefGoogle Scholar
  6. Choi HS, Ko BS, Kim HD, Hong KB, Suh HJ. Effect of valerian/hop mixture on sleep-related behaviors in Drosophila melanogaster. Biol. Pharm. Bull. 40: 1101–1110 (2017)CrossRefGoogle Scholar
  7. Chopin J, Dellamonica G, Besson E, Skrzypczakowa L, Budzianowski J, Mabry TJ. C-Galactosylflavones from Polygonatum-multiflorum. Phytochemistry 16: 1999–2001 (1977)CrossRefGoogle Scholar
  8. Coyne L, Lees G, Nicholson RA, Zheng J, Neufield KD. The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro. Br. J. Pharmacol. 135: 1977–1987 (2002)CrossRefGoogle Scholar
  9. Cravatt BF, Prospero-Garcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL, Lerner RA. Chemical characterization of a family of brain lipids that induce sleep. Science 268: 1506–1509 (1995)CrossRefGoogle Scholar
  10. Debnath T, Park DK, Lee BR, Jin HL, Lee SY, Samad NB, Lim BO. Antioxidant activity of inonotus obliquus grown on germinated brown rice extracts. J. Food Biochem. 37: 456–464 (2013a)CrossRefGoogle Scholar
  11. Debnath T, Park SR, Jo JE, Lim BO. Antioxidant and anti-inflammatory activity of Polygonatum sibiricum rhizome extracts. Asian Pac. J. Trop. Dis. 3: 308–313 (2013b)CrossRefGoogle Scholar
  12. Eban-Rothschild A, Appelbaum L, de Lecea L. Neuronal mechanisms for sleep/wake regulation and modulatory drive. Neuropsychopharmacology 43: 937–952 (2018)CrossRefGoogle Scholar
  13. Fang X, Hao JF, Zhou HY, Zhu LX, Wang JH, Song FQ. Pharmacological studies on the sedative-hypnotic effect of semen Ziziphi spinosae (Suanzaoren) and radix et rhizoma Salviae miltiorrhizae (Danshen) extracts and the synergistic effect of their combinations. Phytomedicine 17: 75–80 (2010)CrossRefGoogle Scholar
  14. Ghorbani A, Rakhshandeh H, Sadeghnia HR. Potentiating effects of Lactuca sativa on pentobarbital-induced sleep. Iran J. Pharm. Res. 12: 401–406 (2013)Google Scholar
  15. Gooneratne NS. Complementary and alternative medicine for sleep disturbances in older adults. Clin. Geriatr. Med. 24: 121–138 (2008)CrossRefGoogle Scholar
  16. Heinrich M, Barnes J, Gibbons S, Williamson E. Fundamentals of pharmacognosy and phytotherapy. Churchill Livingstone, Elsevier Science Ltd., UK. (2004)Google Scholar
  17. Irmisch G, Schlafke D, Gierow W, Herpertz S, Richter J. Fatty acids and sleep in depressed inpatients. Prostaglandins Leukot. Essent. Fatty Acids 76: 1–7 (2007)CrossRefGoogle Scholar
  18. Johnston GA. GABAA receptor channel pharmacology. Curr. Pharm. Des. 11: 1867–1885 (2005)CrossRefGoogle Scholar
  19. Kato A, Miura T. Hypoglycemic action of the rhizomes of Polygonatum officinale in normal and diabetic mice. Planta Med. 60: 201–203 (1994)CrossRefGoogle Scholar
  20. Kato M, Phillips BG, Sigurdsson G, Narkiewicz K, Pesek CA, Somers VK. Effects of sleep deprivation on neural circulatory control. Hypertension 35: 1173–1175 (2000)CrossRefGoogle Scholar
  21. Krueger JM, Kubillus S, Shai S, Davenne D. Enhancement of slow-wave sleep by endotoxin and lipid A. Am. J. Physiol. Regul. Integr. Comp. Physiol. 20: 7 (1986)Google Scholar
  22. Lalley-Chareczko L, Segal A, Perlis ML, Nowakowski S, Tal JZ, Grandner MA. Sleep disturbance partially mediates the relationship between intimate partner violence and physical/mental health in women and men. J. Interpers. Violence 32: 2471–2495 (2017)CrossRefGoogle Scholar
  23. Liu L, Dong Q, Dong XT, Fang JN, Ding K. Structural investigation of two neutral polysaccharides isolated from rhizome of Polygonatum sibiricum. Carbohyd. Polym. 70: 304–309 (2007)CrossRefGoogle Scholar
  24. McKenna JT, Zielinski MR, McCarley RW. Neurobiology of REM sleep, NREM sleep homeostasis, gamma band oscillations, Springer, New York, NY. pp 55–77 (2017)Google Scholar
  25. McKinney MK, Cravatt BF. Structure and function of fatty acid amide hydrolase. Annu. Rev. Biochem. 74: 411–432 (2005)CrossRefGoogle Scholar
  26. Mendelson WB, Basile AS. The hypnotic actions of oleamide are blocked by a camabinoid receptor antagonist. Neuroreport 10: 3237–3239 (1999)CrossRefGoogle Scholar
  27. Okuyama E, Hasegawa T, Matsushita T, Fujimoto H, Ishibashi M, Yamazaki M. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem. Pharm. Bull. 49: 154–160 (2001)CrossRefGoogle Scholar
  28. Portas CM, Bjorvatn B, Ursin R. Serotonin and the sleep/wake cycle: special emphasis on microdialysis studies. Prog. Neurobiol. 60: 13–35 (2000)CrossRefGoogle Scholar
  29. Qadir A, Singh SP, Akhtar J, Ali A, Arif M. Phytochemical and GC-MS analysis of Saudi Arabian Ajwa variety of date seed oil and extracts obtained by the slow pyrolysis method. Orient. Pharm. Exp. Med. 17: 81–87 (2017)CrossRefGoogle Scholar
  30. Risa J, Risa A, Adsersen A, Gauguin B, Stafford GI, van Staden J, Jager AK. Screening of plants used in southern Africa for epilepsy and convulsions in the GABA(A)-benzodiazepine receptor assay. J. Ethnopharmacol. 93: 177–182 (2004)CrossRefGoogle Scholar
  31. Shi Y, Dong J-W, Zhao J-H, Tang L-N, Zhang J-J. Herbal insomnia medications that target GABAergic systems: a review of the psychopharmacological evidence. Curr. Neuropharmacol. 12: 289–302 (2014)CrossRefGoogle Scholar
  32. Sivertsen B, Krokstad S, Overland S, Mykletun A. The epidemiology of insomnia: associations with physical and mental health. The HUNT-2 study. J. Psychosom. Res. 67: 109–116 (2009)CrossRefGoogle Scholar
  33. Son KH, Do JC, Kang SS. Steroidal saponins from the rhizomes of Polygonatum sibiricum. J. Nat. Prod. 53: 333–339 (1990)CrossRefGoogle Scholar
  34. Srivastava JK, Shankar E, Gupta S. Chamomile: a herbal medicine of the past with bright future. Mol. Med. Report. 3: 895–901 (2010)Google Scholar
  35. Sun L, Li X. Studies on chemical constituents of Polygonatum sibiricum (II). Zhongcaoyao 32: 586–588 (2001)Google Scholar
  36. Sun LR, Li X, Wang SX. Two new alkaloids from the rhizome of Polygonatum sibiricum. J. Asian Natural Prod. Res. 7: 127–130 (2005)CrossRefGoogle Scholar
  37. Thomas EA, Carson MJ, Sutcliffe JG. Oleamide-induced modulation of 5-hydroxytryptamine receptor-mediated signaling. Ann. N. Y. Acad. Sci. 861: 183–189 (1998)CrossRefGoogle Scholar
  38. Villet S, Vacher V, Colas A, Danno K, Masson J-L, Marijnen P, Bordet M-F. Open-label observational study of the homeopathic medicine Passiflora compose for anxiety and sleep disorders. Homeopathy 105: 84–91 (2016)CrossRefGoogle Scholar
  39. Wang YM, Zhao JQ, Yang JL, Tao YD, Mei LJ, Shi YP. Chemical constituents from Ligularia purdomii (Turrill) Chittenden. Biochem. Syst. Ecol. 72: 8–11 (2017)CrossRefGoogle Scholar
  40. Williamson EM. Synergy and other interactions in phytomedicines. Phytomedicine 8: 401–409 (2001)CrossRefGoogle Scholar
  41. Yan L, Cheng XR, Zeng Q, Qin JJ, Zhang WD, Jin HZ. Phytane and neoclerodane diterpenes from the aerial parts of Inula nervosa wall. Biochem. Syst. Ecol. 39: 700–703 (2011)CrossRefGoogle Scholar
  42. Yang H, Lee YC, Han KS, Singh H, Yoon M, Park JH, Cho CW, Cho S. Green and gold kiwifruit peel ethanol extracts potentiate pentobarbital-induced sleep in mice via a GABAergic mechanism. Food Chem. 136: 160–163 (2013)CrossRefGoogle Scholar
  43. Yang JY, Wu CF, Song HR. Studies on the sedative and hypnotic effects of oleamide in mice. Arzneimittelforschung 49: 663–667 (1999)Google Scholar
  44. Yehuda S, Rabinovitz S, Mostofsky DI. Essential fatty acids and sleep: mini-review and hypothesis. Med. Hypotheses 50: 139–145 (1998)CrossRefGoogle Scholar
  45. Yost CS, Hampson AJ, Leonoudakis D, Koblin DD, Bornheim LM, Gray AT. Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration. Anesth. Analg. 86: 1294–1300 (1998)Google Scholar
  46. Yuan Q, Joiner WJ, Sehgal A. A sleep-promoting role for the Drosophila serotonin receptor 1A. Curr. Biol. 16: 1051–1062 (2006)CrossRefGoogle Scholar
  47. Zhang DY, Tashiro M, Shibuya K, Okamura N, Funaki Y, Yoshikawa T, Kato M, Yanai K. Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography. J. Clin. Psychopharmacol. 30: 694–701 (2010)CrossRefGoogle Scholar
  48. Zheng H, Dong Z, She J. Modernization of traditional chinese medicine and application. Xueyuan Press, Beijing, China. pp. 4071–4074 (1998)Google Scholar

Copyright information

© The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Public Health ScienceKorea UniversitySeoulRepublic of Korea
  2. 2.Skin Biotechnology CenterKyung Hee UniversityYonginRepublic of Korea
  3. 3.Department of Food Science and TechnologySeoul Women’s UniversitySeoulRepublic of Korea

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