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Food Science and Biotechnology

, Volume 28, Issue 1, pp 237–242 | Cite as

Ginsenosides from Korean red ginseng modulate T cell function via the regulation of NF-AT-mediated IL-2 production

  • Le Ba Vinh
  • Jung Up Park
  • Le Xuan Duy
  • Nguyen Thi Minh Nguyet
  • Seo Young Yang
  • Young Ran Kim
  • Young Ho KimEmail author
Article
  • 198 Downloads

Abstract

Korean red ginseng is a traditional health food frequently used to prevent or treat various diseases worldwide. In this study, we evaluated the immunomodulatory activities of eleven compounds (1–11) isolated from Korean red ginseng, focusing on T cell function. First, the effects of the eleven compounds were studied on the regulation of IL-2, a potent T cell growth factor. Compounds 5, 7, and 9 significantly increased IL-2 secretion in phorbol 12-myristate 13-acetate (PMA)/ionomycin (Io)-induced EL-4 T cells. Next, we examined the effects of compounds 5, 7, and 9 on the regulation of transcription factors related to IL-2 production in T cells. Compound 9 significantly increased the PMA/Io-induced promoter activity of nuclear factor of activated T cells (NF-AT) in EL-4 T cells, but did not have any significant effects on the promoters of NF- κB. These results suggest that compound 9 activates T cell function via the regulation of NF-AT-mediated IL-2 production.

Keywords

Panax ginseng Korean red ginseng Ginsenosides IL-2 

Notes

Acknowledgements

This research was financially supported by the Priority Research Center Program (Code: 2009-0093815) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology Korea.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

10068_2018_428_MOESM1_ESM.pdf (95 kb)
Supplementary material 1 (PDF 94 kb)

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Copyright information

© The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Le Ba Vinh
    • 1
    • 2
  • Jung Up Park
    • 3
  • Le Xuan Duy
    • 1
    • 4
  • Nguyen Thi Minh Nguyet
    • 1
  • Seo Young Yang
    • 1
  • Young Ran Kim
    • 3
  • Young Ho Kim
    • 1
    Email author
  1. 1.College of PharmacyChungnam National UniversityDaejeonRepublic of Korea
  2. 2.Institute of Marine Biochemistry (IMBC)Vietnam Academy of Science and Technology (VAST)HanoiVietnam
  3. 3.College of Pharmacy and Research Institute of Drug DevelopmentChonnam National UniversityGwangjuRepublic of Korea
  4. 4.Institute of Natural Products ChemistryVietnam Academy of Science and Technology (VAST)HanoiVietnam

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