Combined effects of Diospyros lotus leaf and grape stalk extract in high-fat-diet-induced obesity in mice

  • Denis Nchang Che
  • Hyun Ju Kang
  • Byoung Ok Cho
  • Jae Young Shin
  • Seon Il JangEmail author


The aim of this study was to investigate the combined effects of Diospyros lotus leaves extracts (DLE) and Muscat Bailey A grape stalk extracts (MGSE) in obesity induced by high-fat diet (HFD) in mice. The mice were fed with HFD and orally administered daily with DLE, MGSE, a mixture of DLE and MGSE, and Garcinia cambogia extract over a period of 16 weeks. The results revealed that daily administration of DLE and MGSE mixtures markedly prevented HFD-induced weight gain, plasma lipid profile, hepatic steatosis, hepatic fibrosis, diabetic symptoms, and the risk of developing cardiovascular diseases. Also, DLE and MGSE mixtures administration greatly prevented oxidative stress and liver toxicity. The combined effects of DLE and MGSE mixtures were higher than effects of the single extracts and of G. cambogia, a plant known for its anti-obesity effects. In summary, these findings demonstrated that DLE and MGSE mixtures, exhibit anti-obesity activity in HFD-fed mice.


Combined effect Diospyros lotus leaf Muscat Bailey A grape stalk Obesity 



This research was financially supported by the Ministry of SMEs and Startups (MSS), Korea, under the “Regional Specialized Industry Development Program (R&D, Project Number R0006168)” supervised by the Korea Institute for Advancement of Technology (KIAT).

Compliance with ethical standards

Conflict of interest

Theses authors declare that there are no conflict of interest.


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Copyright information

© The Korean Society of Food Science and Technology 2019

Authors and Affiliations

  1. 1.Department of Health ManagementJeonju UniversityJeonjuRepublic of Korea
  2. 2.Department of Food Science and TechnologyChonbuk National UniversityJeonjuRepublic of Korea
  3. 3.Research Institute, Ato Q&A Co., LTDJeonjuRepublic of Korea

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