Ameliorative effects of Lycium chinensis on male sexual dysfunction and testicular oxidative damage in streptozotocin-induced diabetic rats
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The root bark of Lycium chinense (LC) has been reported to have potent antioxidant and antidiabetic properties. In the present study, we investigated the attenuative effect of LC against diabetes induced sexual dysfunction and testicular damages in animal models. Diabetic animals were treated with LC (100 and 400 mg/kg) once daily for 6 weeks. At the end of the treatment, mating behavior tests were performed and the animals were sacrificed for the determination of hormonal profile, oxidative stress indices and sperm analysis. LC administration significantly decreased blood glucose level, enhancement of the antioxidant enzyme activities, restored altered sperm characteristics and markedly improved levels of luteinizing hormone, follicle-stimulating hormone and testosterone as compared to the untreated diabetic animals. Furthermore, LC also improved sperm count, viability, motility, increased the reproductive organs weight. The results obtained indicated that L. chinense has beneficial effects in diabetes sexual dysfunction.
KeywordsLycium chinensis Oxidative stress Spermatogenic dysfunction Antioxidant Diabetes mellitus
Thanks to the Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm (No. BM 2014047) and the Public Science and Technology Research Funds Projects of Ocean (No. 201505023) for their grants.
Compliance with ethical standards
Conflict of interest
All authors declare that they have no conflict of interest.
- Fujii J, Iuchi Y, Matsuki S, Ishii T. Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues. Asian J. Androl. 5: 231–242 (2003)Google Scholar
- Kose E, Sarsılmaz M, Tas U¸ Kavakl A, Turk G, Ozlem Dabak D, Sapmaz H, Ogeturk M. Rose oil inhalation protects against formaldehyde-induced testicular damage in rats. Andrologia. 44: 342–348 (2012)Google Scholar
- Nusier MK, Bataineh HN, Daradkah HM. Adverse effects of rosemary (Rosmarinus officinalis L.) on reproductive function in adult male rats, Exp. Biol. Med. 232: 809–813 (2007)Google Scholar
- Shrilatha B, Muralidhara. Occurrence of oxidative impairments, response of antioxidant defenses and associated biochemical perturbations in male reproductive milieu in the Streptozotocin-diabetic rat. Int. J. Androl. 30: 508–518 (2007)Google Scholar
- Yakubu MT, Akanji MA, Oladiji AT. Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats. Asian J Androl. 7: 399–404 (2005)Google Scholar