Preeclampsia in systemic lupus erythematosus pregnancy: a systematic review and meta-analysis

  • Yuanyuan Dong
  • Feifei Yuan
  • Ziwei Dai
  • Zhihui Wang
  • Ying Zhu
  • Bin WangEmail author
Review Article



The impact of systemic lupus erythematosus (SLE) on preeclampsia is still obscure. This study was performed to systematically assess the association between preeclampsia and SLE.


According to the PRISMA statement, designed literature research was performed in PubMed, Web of Science, and Cochrane Library from inception to June 30, 2018. The pooled risk ratio (RR) of preeclampsia in pregnant SLE patients compared with health controls was synthesized by fixed effect model or random effects model depending on heterogeneity.


Ten studies involving 6,389 SLE patients were included. Pregnant women with SLE have significantly increased risk of preeclampsia (RR = 2.99, 95% CI = 2.31 to 3.88; Z = 8.31, P < 0.001) compared with health controls. Subgroup analysis showed that the risk of preeclampsia was significant (Q = 7.64, P = 0.006) higher in prospective studies (RR = 6.94, 95% CI = 3.59 to 13.42) compared to retrospective studies (RR = 2.60, 95% CI = 2.08 to 3.25).


The present study demonstrated that pregnant SLE patients have a high risk of preeclampsia, suggesting a pivotal role of SLE in the pathogenesis of preeclampsia. For rheumatologists and SLE patients, it is important to maintain inactive disease activity and prevent complications as LN, and the control of traditional risk factors of preeclampsia is also pivotal. Further study focus on the prevention of preeclampsia in SLE is also urgent.


Meta-analysis Preeclampsia Pregnancy Systemic lupus erythematosus 



This study was supported by Grants National Natural Science Foundation of China (No. 81573217). We also appreciate the efforts of all the researchers whose articles were included in this study.

Compliance with ethical standards



Supplementary material

10067_2019_4823_MOESM1_ESM.docx (640 kb)
ESM 1 (DOCX 639 kb)


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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiChina
  2. 2.The Key Laboratory of Major Autoimmune DiseasesAnhui Medical UniversityHefeiChina
  3. 3.Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefeiChina

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