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Familial Mediterranean fever-associated infertility and underlying factors

  • Nuh AtasEmail author
  • Berkan Armagan
  • Erdal Bodakci
  • Hasan Satis
  • Alper Sari
  • Nazife Sule Yasar Bilge
  • Reyhan Bilici Salman
  • Gozde Kubra Yardımcı
  • Hakan Babaoglu
  • Levent Kilic
  • Mehmet Akif Ozturk
  • Berna Goker
  • Seminur Haznedaroglu
  • Timucin Kasifoglu
  • Umut Kalyoncu
  • Abdurrahman Tufan
Original Article
  • 50 Downloads

Abstract

Introduction/objectives

Familial Mediterranean fever (FMF) is characterized by recurrent attacks of fever, serositis, and arthritis, but some patients may experience long-term complications of disease such as infertility/subfertility. The published data about FMF-associated infertility is still limited. The aim of this study is to investigate the frequency and to determine potential factors for FMF-associated infertility/subfertility.

Methods

We enrolled 971 adult patients with FMF. We defined infertility as the failure to conceive after 12 months of regular, unprotected intercourse. All patients fulfilled Tel Hashomer criteria. Demographic data, FMF disease characteristics and genotype data (if available), disease complications, laboratory parameters, and treatment features were recorded.

Results

There were 582 subjects eligible for the present study (mean age 41.05 ± 10.6 years, 65.8% female). MEFV mutations were available in 482 subjects, and 74.9% of subjects were harboring M694 V mutation (25.1% homozygous for M694 V). Infertility was present in 64 patients (14.6% of females and 4% of males). Multivariate analysis showed female sex [odds ratio (OR), 4.47; 95% confidence interval (CI95%) 1.75–11.42; p = 0.002], FMF disease onset < 20 years [OR, 2.99; (CI95% 1.04–8.61);p = 0.04], disease severity (ISSF) [OR, 4.81; (CI95% 2.28–10.17); p < 0.001], and colchicine nonresponse [OR, 2.80; (CI95% 1.17–6.74) p = 0.021] were the independent predictors of infertility. We also observed reversal of infertility in five patients who were treated with IL-1 β antagonists.

Conclusion

Disease severity, FMF disease onset < 20 years, colchicine nonresponse, and female sex were found to be the independent predictors of infertility. The value of effective therapeutic interventions must be determined to treat infertility in these patients.

Key Points

The prevalence of infertility increased in female patients with FMF.

• Female sex, FMF disease onset < 20 years, disease severity, and colchicine nonresponse were risk factors for FMF-associated infertility.

• With effective treatment of FMF, reversal of infertility was observed in five patients.

Keywords

Colchicine resistance Familial Mediterranean fever Infertility Inflammation Interleukin-1 β antagonists 

Notes

Funding information

This work was supported by grants from Hacettepe Rheumatology Association. Grant No. HRD2018-001.

Compliance with ethical standards

Disclosures

None.

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  • Nuh Atas
    • 1
    Email author
  • Berkan Armagan
    • 2
  • Erdal Bodakci
    • 3
  • Hasan Satis
    • 1
  • Alper Sari
    • 2
  • Nazife Sule Yasar Bilge
    • 3
  • Reyhan Bilici Salman
    • 1
  • Gozde Kubra Yardımcı
    • 2
  • Hakan Babaoglu
    • 1
  • Levent Kilic
    • 2
  • Mehmet Akif Ozturk
    • 1
  • Berna Goker
    • 1
  • Seminur Haznedaroglu
    • 1
  • Timucin Kasifoglu
    • 3
  • Umut Kalyoncu
    • 2
  • Abdurrahman Tufan
    • 1
  1. 1.Division of Rheumatology, Department of Internal Medicine, Faculty of MedicineGazi UniversityAnkaraTurkey
  2. 2.Division of Rheumatology, Department of Internal Medicine, Faculty of MedicineHacettepe UniversityAnkaraTurkey
  3. 3.Division of Rheumatology, Department of Internal Medicine, Faculty of MedicineOsmangazi UniversityEskisehirTurkey

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