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Utilize lung ultrasound B-lines and KL-6 to monitor anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis-associated interstitial lung disease: a case report and literature review

  • Yukai WangEmail author
  • Shaoqi ChenEmail author
  • Zhangzhang Lin
  • Jianqun Lin
  • Xuezhen Xie
  • Qisheng Lin
  • Guangzhou Du
  • Xiufeng Huang
  • Marco Matucci-Cerinic
  • Daniel E Furst
Case Based Review
  • 3 Downloads

Abstract

In the past decade, lung ultrasound (LUS) B-lines and serum Krebs von den Lungen-6 (KL-6) antigen have been recognized as biomarkers of the connective tissue disease-associated interstitial lung diseases (CTD-ILDs). Robust data have demonstrated that B-lines total numbers and KL-6 levels are correlated with high-resolution computed tomography findings, pulmonary function test, and some clinical parameters in CTD-ILDs. However, limited data are available regarding the use of these two biomarkers to follow CTD-ILDs. Herein, we report a case with anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis-associated ILD, successfully treated with high-dose methylprednisolone, cyclophosphamide, intravenous immunoglobulin, pirfenidone, and followed using lung ultrasound and KL-6.

Keywords

Anti-MDA-5 antibody B-lines Clinically amyopathic dermatomyositis Follow-up Interstitial lung disease KL-6 

Notes

Compliance with ethical standards

Disclosures

None.

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  • Yukai Wang
    • 1
    • 2
    Email author
  • Shaoqi Chen
    • 3
    Email author
  • Zhangzhang Lin
    • 4
  • Jianqun Lin
    • 1
  • Xuezhen Xie
    • 1
  • Qisheng Lin
    • 1
  • Guangzhou Du
    • 5
  • Xiufeng Huang
    • 6
  • Marco Matucci-Cerinic
    • 2
  • Daniel E Furst
    • 7
  1. 1.Department of Rheumatology and ImmunologyShantou Central HospitalShantouChina
  2. 2.Department of Geriatric Medicine, Division of Rheumatology AOUCUniversity of FlorenceFlorenceItaly
  3. 3.Department of UltrasoundThe First Affiliated Hospital of Shantou University Medical CollegeShantouChina
  4. 4.Department of RadiologyJieyang People’s HospitalJieyangChina
  5. 5.Department of RadiologyShantou Central HospitalShantouChina
  6. 6.Department of Respiratory MedicineShantou Central HospitalShantouChina
  7. 7.Division of Rheumatology, Department of MedicineUniversity of California at Los AngelesLos AngelesUSA

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