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Distinction between MPO-ANCA and PR3-ANCA-associated glomerulonephritis in Chinese patients: a retrospective single-center study

  • Yan Hong
  • Pengxian Shi
  • Xia Liu
  • Liu Yang
  • Kang Li
  • Feng Xu
  • Shaoshan Liang
  • Zhengzhao Liu
  • Haitao Zhang
  • Yinghua ChenEmail author
  • Weixin HuEmail author
Original Article
  • 17 Downloads

Abstract

Objectives

To retrospectively investigate the clinical and histological features and outcomes of ANCA-associated glomerulonephritis (AAGN) with different ANCA serotypes.

Method

A total of 467 AAGN patients were divided into MPO-AAGN (MPO) and PR3-AAGN (PR3) groups according to ANCA serotype. Clinical and histological features and renal outcomes were compared.

Results

In this study, 429 (91.9%) patients tested positive for MPO-ANCA, and 38 (8.1%) for PR3-ANCA. The median age at diagnosis (P = 0.017) and proportion of females (P = 0.003) were higher in the MPO group. Joint (P < 0.001), ENT (P = 0.000), skin (P = 0.007), and eye (P = 0.014) involvements were more common in the PR3 group. Compared with that in the PR3-group, a higher proportion of patients in the MPO group had microscopic polyangiitis (P = 0.000), and a lower proportion of exhibited granulomatosis with polyangiitis (P = 0.000). Patients in the MPO group also exhibited lower BVAS scores (P = 0.003) and higher serum albumin levels (P = 0.009). Histologically, a lower proportion of MPO patients had crescentic glomerulonephritis (P = 0.028) and acute tubule-interstitial lesion scores (P = 0.007), but a higher proportion of these patients exhibited mixed class glomerulonephritis (P = 0.032) than in the PR3 group. The relapse rate was lower (P = 0.020), and the 5-year relapse-free survival rate (P = 0.003) was higher in the MPO group than in the PR3 group. However, the 5-year renal survival rates (P = 0.106) were not significantly different.

Conclusions

MPO-ANCA was predominant in Chinese patients with ANCA-associated vasculitis and renal disease. The epidemiological characteristics, extra-renal involvement, and histopathological classes and outcomes were different between MPO-positive and PR3-positive patients, implying that they might be two different disease entities.

Keywords

Antineutrophil cytoplasmic antibody Glomerulonephritis Myeloperoxidase Proteinase 3 

Notes

Funding information

This study was supported by the Natural Science Foundation of China (81770701) and the National Key Research and Development Program of China (2016YFC0904103).

Compliance with ethical standards

Ethical approval of the study was obtained from the ethics committee of Nanjing Jinling Hospital, Nanjing, China. This study was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All patients gave their informed consent prior to their inclusion in the study.

Disclosures

None.

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  • Yan Hong
    • 1
    • 2
  • Pengxian Shi
    • 1
  • Xia Liu
    • 3
  • Liu Yang
    • 3
  • Kang Li
    • 3
  • Feng Xu
    • 3
  • Shaoshan Liang
    • 3
  • Zhengzhao Liu
    • 3
  • Haitao Zhang
    • 3
  • Yinghua Chen
    • 3
    Email author
  • Weixin Hu
    • 1
    • 3
    Email author
  1. 1.Jinling Clinical Medical College of Nanjing Medical UniversityNanjingChina
  2. 2.The Affiliated Wuxi No. 2 People’s Hospital of Nanjing Medical UniversityWuxiChina
  3. 3.National Clinical Research Centre of Kidney Diseases, Nanjing Jinling HospitalNanjing University School of MedicineNanjingChina

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