Autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease adult patients in France: analysis of the long-term outcome from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)

  • Perrine Guillaume-Jugnot
  • Manuela Badoglio
  • Myriam Labopin
  • Louis Terriou
  • Ibrahim Yakoub-Agha
  • Thierry Martin
  • Bruno Lioure
  • Zora Marjanovic
  • Didier Blaise
  • Stéphanie Nguyen
  • Gregory Pugnet
  • Anne Huynh
  • Christophe Deligny
  • Christophe Seinturier
  • Frédéric Garban
  • Laure Swiader
  • Jacques-Olivier Bay
  • Thorsten Braun
  • Régis Peffault de Latour
  • Marie Thérèse Rubio
  • Dominique FargeEmail author
Original Article



The use of autologous haematopoietic stem cell transplantation (AHSCT) in autoimmune disease (AD) patients has increased progressively worldwide. We retrospectively analysed the long-term outcome of AHSCT for AD reported to the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC).


All French AD patients (≥ 18 years at transplant) with a first AHSCT between 1997 and 2013 were included. Primary data were derived from the European Society for Blood and Marrow Transplantation (EBMT) registry, and additional data were obtained through a specific questionnaire designed for the study. Primary end-point was overall survival (OS). Secondary end points were progression-free survival (PFS) and non-relapse mortality (NRM).


Ninety-four AD patients were included, of whom 71% suffered from rheumatologic diseases (n = 67, including 56 systemic sclerosis (SSc)), 16% from neurological disease (n = 15, including 14 multiple sclerosis (MS)) and 13% from various other AD (n = 12). After a median (interquartile range, IQR) follow-up of 83 months (38–130), OS at 5 and 10 years were 77% (95% CI 68.5–86.2) and 64% (95% CI 51.7–76.3), and for PFS 51% (95% CI 40.4–61.6) and 44% (95% CI 32.8–55.3), respectively. Overall, NRM was 8.7% (95% CI 4.0–15.5) at day 100, 9.8% (95% CI 4.8–16.9) at 5 years and 13.6% (95% CI 6.9–22.5) at 10 years.


This first SFGM-TC retrospective report shows long-term benefit of AHSCT in AD patients with acceptable toxicity.


Adult patients Autoimmune disease Autologous Haematopoietic stem cell transplantation 



The authors would like to thank all physicians and professionals who participated in this study:

Mathieu Allez (Paris Saint Louis)

Pauline Belenotti (Marseille)

Denis Caillot (Dijon)

Frederick Christy (Marseille)

Catherine Cordonnier (Créteil)

Audrey Cras (Paris Saint Louis)

Eric Deconinck (Besancon)

Elisabeth Diot (Tours)

Guillaume Drugmanne (Brest)

Nathalie Hugon (Poitiers)

Pauline Lansiaux (Paris Saint Louis)

Thierry Le Gall (Brest)

Xavier Mariette (KB)

Mauricette Michalet (Lyon)

Marc Michel (Créteil)

Luc Mouthon (Cochin)

Vivane Queyrel (Nice)

Danielle Ragonneau (Dijon)

Myriam Renault (Lyon)

Pascal Roblot (Poitiers)

Florence Sarrot-Reynauld (Grenoble)

Compliance with ethical standards

This study was performed in accordance with the ethical guidelines of the 1975 Declaration of Helsinki. Informed consent was obtained from all patients before AHSCT.




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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  • Perrine Guillaume-Jugnot
    • 1
    • 2
  • Manuela Badoglio
    • 3
    • 4
  • Myriam Labopin
    • 4
    • 5
  • Louis Terriou
    • 6
  • Ibrahim Yakoub-Agha
    • 7
  • Thierry Martin
    • 8
  • Bruno Lioure
    • 9
  • Zora Marjanovic
    • 10
  • Didier Blaise
    • 11
  • Stéphanie Nguyen
    • 2
    • 12
  • Gregory Pugnet
    • 13
  • Anne Huynh
    • 14
  • Christophe Deligny
    • 15
  • Christophe Seinturier
    • 16
  • Frédéric Garban
    • 17
  • Laure Swiader
    • 18
  • Jacques-Olivier Bay
    • 19
  • Thorsten Braun
    • 20
  • Régis Peffault de Latour
    • 21
    • 22
  • Marie Thérèse Rubio
    • 23
    • 24
  • Dominique Farge
    • 22
    • 25
    • 26
    • 27
    Email author
  1. 1.Département de Médecine Interne et Immunologie Clinique, APHPHôpital La Pitié SalpêtrièreParisFrance
  2. 2.Université Pierre et Marie CurieParisFrance
  3. 3.EBMT Paris study officeSaint Antoine HospitalParisFrance
  4. 4.Université Pierre et Marie CurieParisFrance
  5. 5.EBMT Paris study office, Department of HaematologySaint Antoine HospitalParisFrance
  6. 6.Service de Médecine Interne et Hématologie, CHRU LilleHôpital Claude HuriezLilleFrance
  7. 7.Service des Maladies du sangCHRU Lille, Hôpital Claude HuriezLilleFrance
  8. 8.Service d’Immunologie Clinique, VIH et Médecine Interne, CHRU StrasbourgNouvel Hôpital CivilStrasbourg CedexFrance
  9. 9.Service d’HématologieHôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg (HUS)StrasbourgFrance
  10. 10.Service d’Hématologie, APHPHôpital Saint AntoineParisFrance
  11. 11.Institut Paoli-Calmettes, CLCC Institut Paoli-CalmettesMarseille Cedex 9France
  12. 12.Service Hématologie Clinique, APHPHôpital La Pitié SalpêtrièreParisFrance
  13. 13.Service de Médecine Interne, CHU ToulouseHôpital PurpanToulouseFrance
  14. 14.Service d’hématologie, CHU / IUCT Oncopole de ToulouseInstitut Universitaire du Cancer de ToulouseToulouse Cedex 9France
  15. 15.Service de Rhumatologie et de Médecine Interne, CHU MartiniqueHôpital P. Zobda-QuitmanFort de FranceFrance
  16. 16.Service de Médecine Vasculaire, Pôle pluridisciplinaire de Médecine, CHU Grenoble Alpes, Site NordHôpital Couple EnfantGrenoble Cedex 9France
  17. 17.Service d’Hématologie, Pôle cancer et Maladies du SangCHU Grenoble Alpes CS10217Grenoble Cedex 9France
  18. 18.Département de Médecine Interne, APHMHôpital de la TimoneMarseille Cedex 05France
  19. 19.Service de Thérapie Cellulaire et Hématologie Clinique, CHU de Clermont FerrandHôpital d’EstaingClermont Ferrand Cedex 1France
  20. 20.Service d’Hématologie, APHPHôpital d’AvicenneBobignyFrance
  21. 21.Service d’Hématologie et Greffe de Moelle, APHPHôpital St-LouisParisFrance
  22. 22.Université Denis DiderotParisFrance
  23. 23.Service d’Hématologie, CHRU NancyHôpital BraboisVandoeuvre les NancyFrance
  24. 24.IMoPA, CNRS UMR 7365Université de LorraineVandoeuvre les NancyFrance
  25. 25.Unité de Médecine Interne: Maladies Auto-immunes et Pathologie Vasculaire (UF 04), Institut Universitaire d’Hématologie EA3518, APHPHôpital St-LouisParisFrance
  26. 26.Centre de Référence des Maladies auto-immunes systémiques Rares d’Ile-de-France (site constitutif)Filière FAI2R, SFGM-TCLilleFrance
  27. 27.Département de MédecineUniversité McGillMontrealCanada

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