Clinical Rheumatology

, Volume 38, Issue 2, pp 385–395 | Cite as

Osteoporosis: a clinical and pharmacological update

  • Maritza VidalEmail author
  • Ross J. Thibodaux
  • Luis Fernando Vidal Neira
  • Osvaldo Daniel Messina
Review Article


Osteoporosis is characterized by the loss of bone mass, deterioration of the bone microarchitecture, and an increased risk of fractures; these later complications are associated with significant morbidity and mortality. The asymptomatic and progressive nature of osteoporosis underscores the importance of identifying this entity in early stages. Despite the various treatments available, the prevention of the disease represents the most important aspect of management. An adequate intake of calcium and vitamin D as well as a healthy lifestyle is the basis for maintaining bone health. When osteoporosis is diagnosed, the choice of medications must be individualized considering characteristics of the patient and the risk of fractures. In this article, we review the main causes of osteoporosis, when and how to start treatment, and appropriate therapy and monitoring.


Bone mineral density Fractures Osteoporosis Osteoporosis treatment 


Compliance with ethical standards




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Copyright information

© International League of Associations for Rheumatology (ILAR) 2018

Authors and Affiliations

  1. 1.Centro de Diagnóstico de Osteoporosis y Enfermedades Reumáticas (CEDOR)LimaPeru
  2. 2.Division of RheumatologyLSU Health Sciences Center - New OrleansNew OrleansUSA
  3. 3.Hospital María AuxiliadoraLimaPeru
  4. 4.International Osteoporosis Foundation (IOF)NyonSwitzerland
  5. 5.Hospital Cosme ArgerichBuenos AiresArgentina
  6. 6.International Osteoporosis Foundation (IOF)Buenos AiresArgentina

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