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Concomitant association of giant cell arteritis and malignancy: a multicenter retrospective case-control study

  • S. Deshayes
  • E. Liozon
  • N. Chanson
  • K. Sacré
  • T. Moulinet
  • C. Blanchard-Delaunay
  • O. Espitia
  • M. Groh
  • M. Versini
  • T. Le Gallou
  • J.-E. Kahn
  • V. Grobost
  • S. Humbert
  • M. Samson
  • R. Mourot Cottet
  • K. Mazodier
  • A. Dartevel
  • J. Campagne
  • A. Dumont
  • B. Bienvenu
  • M. Lambert
  • A. Daumas
  • D. Saadoun
  • A. Aouba
  • H. de BoyssonEmail author
  • on behalf of the French Study Group for Large Vessel Vasculitis (GEFA)
Original Article
Part of the following topical collections:
  1. Autoimmune Collection 2018

Abstract

Introduction

Some studies suggest that there is an increased risk of malignancies in giant cell arteritis (GCA). We aimed to describe the clinical characteristics and outcomes of GCA patients with concomitant malignancy and compare them to a GCA control group.

Method

Patients with a diagnosis of GCA and malignancy and with a maximal delay of 12 months between both diagnoses were retrospectively included in this study and compared to a control group of age-matched (3:1) patients from a multicenter cohort of GCA patients.

Results

Forty-nine observations were collected (median age 76 years). Malignancies comprised 33 (67%) solid neoplasms and 16 (33%) clonal hematologic disorders. No over-representation of a particular type of malignancy was observed. Diagnosis of GCA and malignancy was synchronous in 7 (14%) patients, while malignancy succeeded GCA in 29 (59%) patients. Malignancy was fortuitously diagnosed based on abnormalities observed in laboratory tests in 26 patients, based on imaging in 14 patients, and based on symptoms or clinical examination in the nine remaining patients. Two patients had a concomitant relapse of both conditions. When compared to the control group, patients with concomitant GCA and malignancy were more frequently male (p < 0.001), with an altered general state (p < 0.001), and polymyalgia rheumatica (p < 0.01).

Conclusions

This study does not indicate an over-representation of any particular type of malignancy in GCA patients. Initial follow-up dictated by vasculitis may have led to an early identification of malignancy. Nevertheless, GCA male patients with an altered general state and polymyalgia rheumatica might more frequently show concomitant malignancies.

Keywords

Giant cell arteritis Hematologic neoplasms Malignancy Neoplasms 

Notes

Compliance with ethical standards

Ethical standards

This study was conducted in compliance with good clinical practices and the Declaration of Helsinki principles. At the time of this study, in accordance with French public health law (Art. L 1121-1-1, Art. L 1121-1-2), formal approval from an ethics committee was not required for this type of observational study. Our local ethics committee confirmed the observational non-interventional retrospective nature of our cohort.

Conflicts of interest

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Maxime Samson declares invitations to congresses by Abbvie, Roche Chugaï, Actelion, Novartis and LFB; symposium for Roche Chugaï and belongs to scientific committee of Roche Chugaï. The other authors declare that they have no relevant financial interests.

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  • S. Deshayes
    • 1
  • E. Liozon
    • 2
  • N. Chanson
    • 3
  • K. Sacré
    • 3
  • T. Moulinet
    • 4
  • C. Blanchard-Delaunay
    • 5
  • O. Espitia
    • 6
  • M. Groh
    • 7
  • M. Versini
    • 8
  • T. Le Gallou
    • 9
  • J.-E. Kahn
    • 10
  • V. Grobost
    • 11
  • S. Humbert
    • 12
  • M. Samson
    • 13
  • R. Mourot Cottet
    • 14
  • K. Mazodier
    • 15
  • A. Dartevel
    • 16
  • J. Campagne
    • 17
  • A. Dumont
    • 1
  • B. Bienvenu
    • 18
  • M. Lambert
    • 19
  • A. Daumas
    • 20
  • D. Saadoun
    • 21
  • A. Aouba
    • 1
  • H. de Boysson
    • 1
    Email author
  • on behalf of the French Study Group for Large Vessel Vasculitis (GEFA)
  1. 1.Department of Internal Medicine and Clinical ImmunologyNormandie Univ, UNICAEN, CHU de Caen NormandieCaenFrance
  2. 2.Department of Internal MedicineCHU LimogesLimogesFrance
  3. 3.Department of Internal MedicineHôpital BichatParisFrance
  4. 4.Department of Internal MedicineHôpitaux Privés de MetzMetzFrance
  5. 5.Department of Internal MedicineCentre Hospitalier Georges RenonNiortFrance
  6. 6.Department of Internal MedicineCHU NantesNantesFrance
  7. 7.Department of Internal Medicine, National Referral Center for Hypereosinophilic Syndromes (CEREO)Hôpital FochSuresnesFrance
  8. 8.Institut Arnault TzanckSaint Laurent du VarFrance
  9. 9.Department of Internal MedicineCHU RennesRennesFrance
  10. 10.Department of Internal MedicineHôpital Ambroise ParéBoulogne BillancourtFrance
  11. 11.Department of Internal MedicineCHU EstaingClermont-FerrandFrance
  12. 12.Department of Internal MedicineCHU de BesançonBesançonFrance
  13. 13.Department of Internal Medicine and Clinical ImmunologyCHU DijonDijonFrance
  14. 14.Department of Internal MedicineHôpital CivilStrasbourgFrance
  15. 15.Department of Internal MedicineHôpital de la ConceptionMarseilleFrance
  16. 16.Department of Internal MedicineCHU GrenobleGrenobleFrance
  17. 17.Department of Infectious and Systemic DiseasesHôpital d’Instruction des ArméesMetzFrance
  18. 18.Department of Internal MedicineHôpital Saint JosephMarseilleFrance
  19. 19.Department of Internal MedicineCHU de LilleLilleFrance
  20. 20.Department of Geriatric and Internal MedicineCHU de MarseilleMarseilleFrance
  21. 21.Department of Internal MedicineHôpital Pitié SalpétrièreParisFrance

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