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A simulation tool for mechanical circulatory support device interaction with diseased states

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Abstract

We have created a simulation model to investigate the interactions between a variety of mechanical circulatory support (MCS) devices and the circulatory system with various simulated patient conditions and disease states. The present simulation accommodates a family of continuous-flow MCS devices under various stages of consideration or development at our institution. This article describes the mathematical core of the in silico simulation system and shows examples of simulation output imitating various disease states and of selected in vitro and clinical data from the literature.

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References

  1. 1.

    Horvath D, Byram N, Karimov JH, Kuban B, Sunagawa G, Golding LAR, et al. Mechanism of self-regulation and in vivo performance of the Cleveland Clinic continuous-flow total artificial heart. Artif Organs. 2017;41:411–7.

  2. 2.

    Horvath D, Karimov JH, Byram N, Kuban B, Golding LA, Moazami N, et al. Sensorless suction recognition in the self-regulating Cleveland Clinic continuous-flow total artificial heart. ASAIO J. 2015;61:726–8.

  3. 3.

    Karimov JH, Moazami N, Kobayashi M, Sale S, Such K, Byram N, et al. First report of 90-day support of 2 calves with a continuous-flow total artificial heart. J Thorac Cardiovasc Surg. 2015;150:e1.

  4. 4.

    Saeed D, Ootaki Y, Ootaki C, Akiyama M, Horai T, Catanese J, et al. Acute in vivo evaluation of an implantable continuous flow biventricular assist system. ASAIO J. 2008;54:20–4.

  5. 5.

    Horvath DJ, Horvath DW, Karimov JH, Byram N, Kuban BD, Miyamoto T, Fukamachi K. Use of a mechanical circulatory support simulation to study pump interactions with the variable hemodynamic environment. Artif Organs. 2018;42:E420–E427427.

  6. 6.

    Miyamoto T, Horvath DJ, Horvath DW, Karimov JH, Byram N, Kuban BD, Fukamachi K. Simulated performance of the Cleveland Clinic continuous-flow total artificial heart using the Virtual Mock Loop. ASAIO J. 2018

  7. 7.

    Korakianitis T, Shi Y. Numerical simulation of cardiovascular dynamics with healthy and diseased heart valves. J Biomech. 2006;39:1964–82.

  8. 8.

    Shi Y, Korakianitis T, Bowles C. Numerical simulation of cardiovascular dynamics with different types of VAD assistance. J Biomech. 2007;40:2919–33.

  9. 9.

    Hasania K, Navidbkhsh M, Rostami M. Simulation of the cardiovascular system using equivalent electronic system. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006;150:105–12.

  10. 10.

    Vollkron S, Schima H, Huber L, Wieselthaler G. Interaction of the cardiovascular system with an implanted rotary assist device: simulation study with a refined computer model. Artif Organs. 2002;26:349–59.

  11. 11.

    Bozkurt S, Safak KK. Evaluating the hemodynamical response of a cardiovascular system under support of a continuous flow left ventricular assist device via numerical modeling and simulations. Comput Math Methods Med. 2013;2013:986430.

  12. 12.

    Cuenca-Navalon E, Finocchiaro T, Laumen M, Fritschi A, Schmitz-Rode T, Steinseifer U. Design and evaluation of a hybrid mock circulatory loop for total artificial heart testing. Int J Artif Organs. 2014;37:71–80.

  13. 13.

    Nestler F, Bradley AP, Wilson SJ, Timms DL, Frazier OH, Cohn WE. A hybrid mock circulation loop for a total artificial heart. Artif Organs. 2014;38:775–82.

  14. 14.

    Rich JD, Burkhoff D. HVAD Flow waveform morphologies: theoretical foundations and implications for clinical practice. ASAIO J. 2017;63:526–35.

  15. 15.

    Sunagawa G, Byram N, Karimov JH, Horvath DJ, Moazami N, Starling RC, et al. The contribution to hemodynamics even at very low pump speeds in the HVAD. Ann Thorac Surg. 2016;101:2260–4.

  16. 16.

    Klabunbe RE. Cardiovascular physiology concepts. Revised 12/6/16. https://www.cvphysiology.com/Cardiac%20Function/CF024. Accessed 16 May 2018.

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Funding

The software development was funded by R1 Engineering, LLC (Euclid, Ohio, USA).

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Correspondence to Jamshid H. Karimov.

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Conflict of interest

The software was developed by R1 Engineering, LLC (Euclid, Ohio, USA) in collaboration with Cleveland Clinic. No other authors have a conflict of interest.

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Horvath, D.J., Horvath, D.W., Karimov, J.H. et al. A simulation tool for mechanical circulatory support device interaction with diseased states. J Artif Organs (2020). https://doi.org/10.1007/s10047-020-01155-2

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Keywords

  • Cardiovascular disease
  • Computer simulation
  • Mock circulation loop
  • Lumped parameter
  • Pumps
  • Heart assist