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A simulation tool for mechanical circulatory support device interaction with diseased states

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We have created a simulation model to investigate the interactions between a variety of mechanical circulatory support (MCS) devices and the circulatory system with various simulated patient conditions and disease states. The present simulation accommodates a family of continuous-flow MCS devices under various stages of consideration or development at our institution. This article describes the mathematical core of the in silico simulation system and shows examples of simulation output imitating various disease states and of selected in vitro and clinical data from the literature.

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The software development was funded by R1 Engineering, LLC (Euclid, Ohio, USA).

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Correspondence to Jamshid H. Karimov.

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The software was developed by R1 Engineering, LLC (Euclid, Ohio, USA) in collaboration with Cleveland Clinic. No other authors have a conflict of interest.

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Horvath, D.J., Horvath, D.W., Karimov, J.H. et al. A simulation tool for mechanical circulatory support device interaction with diseased states. J Artif Organs (2020). https://doi.org/10.1007/s10047-020-01155-2

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  • Cardiovascular disease
  • Computer simulation
  • Mock circulation loop
  • Lumped parameter
  • Pumps
  • Heart assist