Pre-clinical assessment of a prototype non-invasive diagnostic device to detect aortic aneurysms

  • Koyu WatanabeEmail author
  • A. Toshimitsu Yokobori
  • Toshihito Ohmi
  • Hiromi Yoshinari
  • Yoshikatsu Saiki
Original Article Others


We have developed a non-invasive diagnostic device for treating thoracic aortic aneurysm that can be applied at a peripheral artery. This study aimed to examine how configuration and size of an aneurysm as well as endoluminal pressure affect our diagnostic device’s ability to detect an aneurysm, using a pulsatile mock circulation. We created three different-sized (12, 16, and 20 mm) saccular and fusiform aneurysm models using silicone and incorporated them in a pulsatile perfusion circuit to evaluate vertical vessel wall velocity wave form at a location apart from the aneurysm. We also varied the pressure condition to evaluate the changes in the detected wave forms. In both fusiform and saccular aneurysm models, biphasic wave forms indicating the presence of aneurysm within the circuit were observed. Regarding aneurysm diameter, biphasic wave forms were observed in all aneurysm models. However, in the 12-mm model, which is relevant to the minimum diameter of clinical diagnostic criteria for an aneurysm relative to normal size, no biphasic waveform was detected when the endoluminal pressure was relatively low. In the 16- and 20-mm models, biphasic waveform was detected without being affected by the configuration and endoluminal pressure. The detectability of aneurysms within a pulsatile mock circulation using our non-invasive diagnostic device was not affected by the clinically relevant configuration and size of the aneurysm under slightly hypertensive endoluminal pressure condition. Low endoluminal pressure may lower the diagnostic sensitivity for relatively small saccular aneurysm.


Thoracic aortic aneurysm Doppler effect Non-invasive diagnostic device 



  1. 1.
    Gen Committee for Scientific Affairs, The Japanese, Association, for Thoracic Surgery, Masuda M, Okumura M, Doki Y, et al. Thoracic and cardiovascular surgery in japan during 2014: annual report by The Japanese Association for Thoracic Surgery. Gen Thoracic Cardiovasc Surg. 2016;64:665–97.CrossRefGoogle Scholar
  2. 2.
    Yokobori AT Jr, Owa M, Ichiki M, et al. The analysis and diagnosis of unstable behavior of the blood vessel wall with an aneurysm based on noise science. J Atheroscler Thromb. 2006;13:163–74.CrossRefGoogle Scholar
  3. 3.
    Yokobori AT Jr, Ohkuma T, Yoshinari H, et al. Acoustical imaging and processing of blood vessel and the related materials using ultrasound doppler effect. Bio-Med Mater Eng. 1991;1:127–36.Google Scholar
  4. 4.
    Yokobori AT Jr, Ohkuma T, Sasaki S, et al. Algorithm of the non-invasive diagnosis method on the atherosclerosis by Ultrasound Doppler effect. Bio-Med Mater Eng. 1994;4:87–96.Google Scholar
  5. 5.
    Yokobori AT Jr, Ichiki M, Tomono Y, et al. Frequency response of blood vessel wall with atherosclerosis and aneurysm. Bio-Med Mater Eng. 2011;21:171–7.Google Scholar
  6. 6.
    Yokobori AT Jr, Sakai S, Yamagiwa K, et al. Quantitative characterization of fracture surface of full lamellar TiAl under high temperature creep and fatigue conditions on the basis of fractal concept. Strength Fract Complexity Int J. 2003;1:19–29.Google Scholar
  7. 7.
    Yokobori AT Jr, Ichiki M, Ohuchi H, et al. The proposal of non-invasive quantitative diagnostic method of the atherosclerosis and the clarification of organ correlation of atherosclerosis and oxygen metabolism. Bio-Med Mater Eng. 2004;14:241–9.Google Scholar
  8. 8.
    Nishikawa Y, Yokobori AT Jr, Kudo K, et al. Master thesis 2016, Dept. of Nano Mechanics faculty of graduate School of engineering Tohoku UniversityGoogle Scholar
  9. 9.
    Karino T. Flow behaviour of blood cells and rigid spheres in an annular vortex. Phil Trans R Soc Lond. 1997;B279:413–45.Google Scholar
  10. 10.
    Macagno EO, Hung T-K. Computational and experimental study of a captive annular eddy. J Fluid Mech. 1967;28:43–66.CrossRefGoogle Scholar
  11. 11.
    Masaki N, Kumagai K, Sasaki K, et al. Suppressive effect of pitavastatin on aortic arch dilatation in acute Stanford type B aortic dissection: analysis of STANP trial. Gen Thorac Cardiovasc Surg. 2018;66:334–43.CrossRefGoogle Scholar
  12. 12.
    Hosoyama K, Kawamoto S, Watanabe K, et al. Safety and durability of the biodegradable felt in aortic surgery: a propensity score-matched study. Eur J Cardiothorac Surg. 2018;54:361–8.CrossRefGoogle Scholar

Copyright information

© The Japanese Society for Artificial Organs 2019

Authors and Affiliations

  • Koyu Watanabe
    • 1
    Email author
  • A. Toshimitsu Yokobori
    • 2
  • Toshihito Ohmi
    • 3
  • Hiromi Yoshinari
    • 4
  • Yoshikatsu Saiki
    • 1
  1. 1.Division of Cardiovascular Surgery, Graduate School of MedicineTohoku UniversitySendaiJapan
  2. 2.Strategic Innovation and Research Center, Laboratory of Strength of Materials and ScienceTeikyo UniversityTokyoJapan
  3. 3.Department of Mechanical EngineeringShonan Institute of TechnologyFujisawaJapan
  4. 4.Medical Material LaboratoryTeikyo UniversityTokyoJapan

Personalised recommendations