Oxygen delivery to the blood stream by the dialysis fluid during continuous renal replacement therapy ex vivo

  • Yoshihiro TangeEmail author
  • Shigenori Yoshitake
Original Article Artificial Lung / ECMO


Continuous renal replacement therapy (CRRT) maintains a balance in body water and electrolytes. CRRT supplies a higher quantity of fluid than intravenous fluid therapy along with simultaneous fluid withdrawal. We hypothesized that use of a high-oxygen-containing solution for high-volume fluid exchange would improve oxygenation in the blood during CRRT. To start with, we prepared a solution containing high oxygen. The objective of this study was to determine if this solution would increase the partial pressure of oxygen (pO2) in the blood more than that using a conventional solution during CRRT. We compared the gas profile of the experimental fluid ex vivo in a simulated CRRT for 24 h, using 2-L batches of bovine blood. A significant increase in the pO2, pH, and total oxygen delivery, and a significant decrease in the partial pressure of carbon dioxide (pCO2) were estimated in the bovine blood using the experimental solution during the simulated CRRT. This method is simpler to apply for oxygenation than the conventional method, and will be beneficial to hypoxic patients in terms of improving their blood oxygenation during CRRT.


Oxygen Carbon dioxide Hypoxia Dialysis fluid Renal replacement therapy 



The authors would like to thank all the colleagues who helped with our experiments.


This research has not received any specific grant from any funding agencies in public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors report no proprietary or commercial interest for any product mentioned or any concept discussed in this article.


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Copyright information

© The Japanese Society for Artificial Organs 2019

Authors and Affiliations

  1. 1.Department of Medical EngineeringKyushu University of Health and WelfareNobeokaJapan

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