Journal of Artificial Organs

, Volume 22, Issue 1, pp 29–36 | Cite as

Shape optimization of a centrifugal blood pump by coupling CFD with metamodel-assisted genetic algorithm

  • Behnam Ghadimi
  • Amir NejatEmail author
  • Seyed Ahmad Nourbakhsh
  • Nasim Naderi
Original Article Artificial Heart (Basic)


A centrifugal blood pump is a common type of pump used as a left ventricular assist device in the medical industries. Therefore, the improvement of the device bio-compatibility to reduce the blood damage and to increase the efficiency has become a major challenge. In the current work, a metamodel-assisted genetic algorithm is employed to simultaneously optimize the impeller and volute geometries of a typical centrifugal blood pump. The overall shape of the base design is inspired from HeartMate3 LVAD, and the main dimensions of the base design including inlet and outlet radius, blade angle distribution, volute cross-section area distribution, etc., are designed in our laboratory. Three different scenarios are investigated using three different objective functions, i.e., (1) hydraulic efficiency, (2) pressure head, and (3) hemolysis index (HI). The results showed that the shape optimized by pump efficiency has also nearly the same level of HI as the shape optimized by HI. Hence, to reduce computation time, one can use efficiency instead of HI as an objective function. However, one must check the HI level after such optimization to see whether it is within the acceptable range of HI for such bio application.


Hemolysis Centrifugal blood pump Optimization Metamodel Genetic algorithm 



This research is sponsored by the Iran National Science Foundation (INSF) with the Project No. of 95837323.

Compliance with ethical standards

Conflict of interest

The authors declared that there are no conflicts of interest.

Supplementary material

10047_2018_1072_MOESM1_ESM.docx (340 kb)
Supplementary material 1 (DOCX 339 KB)


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Copyright information

© The Japanese Society for Artificial Organs 2018

Authors and Affiliations

  • Behnam Ghadimi
    • 1
  • Amir Nejat
    • 1
    Email author
  • Seyed Ahmad Nourbakhsh
    • 1
  • Nasim Naderi
    • 2
  1. 1.School of Mechanical Engineering, College of EngineeringUniversity of TehranTehranIran
  2. 2.Rajaie Cardiovascular, Medical and Research CenterTehranIran

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