Brain Tumor Pathology

, Volume 35, Issue 4, pp 193–201 | Cite as

Stromal cells of hemangioblastomas exhibit mesenchymal stem cell-derived vascular progenitor cell properties

  • Shigeki Takada
  • Masato HojoEmail author
  • Noriyoshi Takebe
  • Kenji Tanigaki
  • Susumu Miyamoto
Original Article


Hemangioblastoma is composed of neoplastic stromal cells and a prominent capillary network. To date, the identity of stromal cells remains unclear. Mesenchymal stem cells can give rise to committed vascular progenitor cells, and ephrin-B2/EphB4 and Notch signaling have crucial roles in these steps. The aim of our study was to elucidate that stromal cells of central nervous system hemangioblastomas have mesenchymal stem cell-derived vascular progenitor cell properties. Ten hemangioblastomas were investigated immunohistochemically. CD44, a mesenchymal stem cell marker, was detected in stromal cells of all cases, suggesting that stromal cells have mesenchymal stem cell-like properties. Neither CD31 nor α-SMA was expressed in stromal cells, suggesting that stromal cells have not acquired differentiated vascular cell properties. Both ephrin-B2 and EphB4, immature vascular cell markers, were detected in stromal cells of all cases. Jagged1, Notch1, and Hesr2/Hey2, which are known to be detected in both immature endothelial cells and mural cells, were expressed in stromal cells of all cases. Notch3, which is known to be detected in differentiating mural cells, was also expressed in all cases. These results suggest that stromal cells also have vascular progenitor cell properties. In conclusion, stromal cells of hemangioblastomas exhibit mesenchymal stem cell-derived vascular progenitor cell properties.


Ephrin-B2/EphB4 signaling Hemangioblastoma Mesenchymal stem cell Notch signaling Stromal cell 



This work was supported by the Japan Society for the Promotion of Science (16689024 to Masato Hojo). We thank Ryota Ito, Mafumi Kurozumi and Toshiaki Manabe for technical assistance.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© The Japan Society of Brain Tumor Pathology 2018

Authors and Affiliations

  1. 1.Department of NeurosurgeryKyoto University Graduate School of MedicineKyotoJapan
  2. 2.Research InstituteShiga Medical CenterMoriyamaJapan
  3. 3.Department of NeurosurgeryShiga Medical Center for AdultsMoriyamaJapan

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