Journal of Solid State Electrochemistry

, Volume 22, Issue 11, pp 3527–3533 | Cite as

Selective determination of L-dopa in the presence of ascorbic acid and uric acid using a 3D graphene foam

  • Hong Yan YueEmail author
  • Hong Zhang
  • Shuo Huang
  • Xin Gao
  • Jing Chang
  • Xuan Yu Lin
  • Long Hui Yao
  • Li Ping Wang
  • Er Jun Guo
Original Paper


Three-dimensional interconnected network graphene foam (GF) was synthesized by chemical vapor deposition. The GF was transferred onto indium tin oxide glass, acting as an electrode for the selective determination of L-dopa in the presence of ascorbic and uric acid. Using differential pulse voltammetry (DPV) method, the oxidation peak current is well linear with L-dopa concentration in the range of 0.05–1 μM with a sensitivity of 2.64 μA μM−1 and in the range of 1–40 μM with a sensitivity of 1.82 μA μM−1. The detection limit of this electrode for L-dopa is about 20 nM. The proposed electrode can also effectively avoid the interference of ascorbic acid and uric acid, making the proposed sensor suitable for the accurate determination of L-dopa in human urine fluids. This electrode will have a wide range of potential application prospect in electrochemical detection.


L-dopa Nickel foam Graphene foam Biosensors 


Funding information

This work is supported by the National Natural Science Foundation of China (51201052), Science Funds for the Young Innovative Talents of HUST (201306) and Postdoctoral Initial Founding of Heilongjiang Province (LBH-Q1260, LBH-Q14117).


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Hong Yan Yue
    • 1
    Email author
  • Hong Zhang
    • 1
  • Shuo Huang
    • 1
    • 2
  • Xin Gao
    • 1
  • Jing Chang
    • 1
  • Xuan Yu Lin
    • 1
  • Long Hui Yao
    • 1
  • Li Ping Wang
    • 1
  • Er Jun Guo
    • 1
  1. 1.School of Materials Science and EngineeringHarbin University of Science and TechnologyHarbinPeople’s Republic of China
  2. 2.Department of NeurologyThe First Affiliated Hospital of Harbin Medical UniversityHarbinPeople’s Republic of China

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