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Journal of Solid State Electrochemistry

, Volume 22, Issue 11, pp 3351–3361 | Cite as

Potentiometric ion-selective electrodes for determination of cyclopentolate hydrochloride and phenylephrine hydrochloride in their challenging ophthalmic formulation

  • Mamdouh R. Rezk
  • Ahmed S. Fayed
  • Hoda M. Marzouk
  • Samah S. Abbas
Original Paper
  • 34 Downloads

Abstract

Introduction of potentiometric ion-selective electrodes (ISEs) opened a new bright area in pharmaceutical analysis acknowledged as being an eco-friendly, simple, and energy-saving technique that is well-suited with microfabrication. In this contribution, potentiometric ISEs were employed as an alternative green analytical tool with the crucial goal of expanding the effective application of the potentiometric sensors in different disciplines of drug-stability studies and quality-control investigations. Four novel cyclopentolate hydrochloride and phenylephrine hydrochloride selective membrane sensors were constructed and evaluated. Sensors’ fabrication was achieved using potassium tetrakis (4-chlorophenyl) borate, a cationic exchanger, in a polyvinyl chloride polymeric matrix plasticized with 2-nitrophenyl octyl ether and using 2-hydroxy propyl-β-cyclodextrin as an ionophore. A comparative potentiometric study was implemented using two designs of ISEs; a conventional liquid inner contact and a glassy carbon solid-contact one. Using solid-contact ISEs, detection limit was substantially decreased and the discriminative ability in the presence of the most interfering substances was enhanced. This permits simultaneous estimation of both drugs, in spite of their similar ionic characteristics, abolishing the need for any pretreatment or separation steps in their challenging combined ophthalmic formulation as well as in rabbit aqueous humor and in the presence of their degradation products.

Keywords

Cyclopentolate hydrochloride Phenylephrine hydrochloride Green analytical chemistry Liquid inner contact electrode Solid-contact electrode Stability-indicating method Rabbit aqueous humor 

Notes

Compliance with ethical standards

Ethical approval

This work was approved by the Institutional Research Ethical Committee at Faculty of Pharmacy, Cairo University.

Supplementary material

10008_2018_4045_MOESM1_ESM.docx (164 kb)
ESM 1 (DOCX 164 kb)

References

  1. 1.
    Abd El-Rahman MK, Zazaa H, Ibrahim NB, Mustafa AA (2016) Just-dip-it (potentiometric ion-selective electrode); an innovative way of greening analytical chemistry. ACS Sustain Chem Eng 4(6):3122–3132CrossRefGoogle Scholar
  2. 2.
    The British Pharmacopoeia, Her Majesty’s Stationary office (2016) LondonGoogle Scholar
  3. 3.
    Sweetman SC (2011) Martindale: the complete drug reference, 37th edn. Pharmaceutical Press, LondonGoogle Scholar
  4. 4.
    Roy AK, Guillory JK (1995) The kinetics and mechanism of the hydrolysis of cyclopentolate hydrochloride in alkaline solutions. Int J Pharm 120(2):169–178CrossRefGoogle Scholar
  5. 5.
    Marin A, Barbas C (2004) LC/MS for the degradation profiling of cough–cold products under forced conditions. J Pharm Biomed Anal 35(5):1035–1045CrossRefPubMedGoogle Scholar
  6. 6.
    Trommer H, Raith K, Neubert RHH (2010) Investigating the degradation of the sympathomimetic drug phenylephrine by electrospray ionization-mass spectrometry. J Pharm Biomed Anal 52(2):203–209CrossRefPubMedGoogle Scholar
  7. 7.
    Rezk MR, Fayed AS, Marzouk HM, Abbas SS (2017) Chromatographic determination of cyclopentolate hydrochloride and phenylephrine hydrochloride in the presence of their potential degradation products. J AOAC Int 100(2):434–444CrossRefPubMedGoogle Scholar
  8. 8.
    Rizk MS, Abdel-Haleem FM (2010) Plastic membrane electrodes for the determination of flavoxate hydrochloride and cyclopentolate hydrochloride. Electrochim Acta 55(20):5592–5597CrossRefGoogle Scholar
  9. 9.
    Shoukry AFI, El-Sheikh R, Issa YM, Zareh M (1989) Potentiometric sensor for phenylephrine based on phenylephrine-tetraphenylborate lipophilic salt. Mikrochim Acta III 101–108CrossRefGoogle Scholar
  10. 10.
    Giahi M, Mirzaei M, Veghar Lahijani G (2010) Potentiometric PVC membrane sensor for the determination of phenylephrine hydrochloride in some pharmaceutical products. J Iran Chem Soc 7(2):333–338CrossRefGoogle Scholar
  11. 11.
    Soleymanpour A, Abdifar S, Bani R (2011) Development of a new coated graphite phenylephrine potentiometric sensor and its applications to pharmaceutical and biological analysis. Electroanalysis 23(12):2813–2821CrossRefGoogle Scholar
  12. 12.
    Rezk MR, Fayed AS, Marzouk HM, Abbas SS (2017) Green ion selective electrode potentiometric application for the determination of cinchocaine hydrochloride in presence of its degradation products and betamethasone valerate: a comparative study of liquid and solid inner contact ion-selective electrode membranes. J Electrochem Soc 164:H628–H634CrossRefGoogle Scholar
  13. 13.
    Abd El-Rahman MK, Rezk MR, Mahmoud AM, Elghobashy MR (2015) Design of a stable solid-contact ion-selective electrode based on polyaniline nanoparticles as ion-to-electron transducer for application in process analytical technology as a real-time analyzer. Sensors Actuators B Chem 208:14–21CrossRefGoogle Scholar
  14. 14.
    Buck RP, Linder E (1994) Recommendations for nomenclature of ion selective electrodes (IUPAC recommendations 1994). Pure Appl Chem 66(12):2527–2536CrossRefGoogle Scholar
  15. 15.
    Prankerd RJ (2007) Profiles of drug substances, excipients and related methodology: critical compilation of pKa values for pharmaceutical substances. Elsevier Academic PressGoogle Scholar
  16. 16.
    Sideris E, Valsami G, Koupparis M, Macheras P (1999) Studies on the interaction of diflunisal ion with cyclodextrins using ion-selective electrode potentiometry. Eur J Pharm Sci 7(4):271–278CrossRefPubMedGoogle Scholar
  17. 17.
    Antoniadou-Vyza E, Buckton G, Michaleas SG, Loukas YL, Efentakis M (1997) The formation of an inclusion complex of methocarbamol with hydroxypropyl-β-cyclodextrin: the effect on chemical stability, solubility and dissolution rate. Int J Pharm 158(2):233–239CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Mamdouh R. Rezk
    • 1
  • Ahmed S. Fayed
    • 1
  • Hoda M. Marzouk
    • 1
  • Samah S. Abbas
    • 1
  1. 1.Analytical Chemistry Department, Faculty of PharmacyCairo UniversityCairoEgypt

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