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High sulfite oxidase expression could predict postoperative biochemical recurrence in patients with prostate cancer

  • Hirofumi Kurose
  • Yoshiki NaitoEmail author
  • Jun Akiba
  • Reiichiro Kondo
  • Sachiko Ogasawara
  • Hironori Kusano
  • Sakiko Sanada
  • Hideyuki Abe
  • Tatsuyuki Kakuma
  • Kosuke Ueda
  • Tsukasa Igawa
  • Hirohisa Yano
Original Paper
  • 28 Downloads

Abstract

Sulfite oxidase (SUOX) is a metalloenzyme that plays a role in ATP synthesis via oxidative phosphorylation in mitochondria and has been reported to also be involved in the invasion and differentiation capacities of tumor cells. Here, we performed a clinicopathological investigation of SUOX expression in prostate cancer and discussed the usefulness of SUOX expression as a predictor of biochemical recurrence following surgical treatment in prostate cancer. This study was conducted using Tissue Micro Array specimens obtained from 97 patients who underwent radical prostatectomy at our hospital between 2007 and 2011. SUOX staining was used to evaluate cytoplasmic SUOX expression. In the high-expression group, the early biochemical recurrence was significantly more frequent than in the low-expression group (p = 0.0008). In multivariate analysis, high SUOX expression was found to serve as an independent prognostic factor of biochemical recurrence (hazard ratio = 2.33, 95% confidence interval = 1.32–4.15, p = 0.0037). In addition, Ki-67-labeling indices were significantly higher in the high-expression group than in the low-expression group (p = 0.0058). Therefore, SUOX expression may be a powerful prognostic biomarker for decision-making in postoperative follow-up after total prostatectomy and with regard to the need for relief treatment.

Keywords

Prostate cancer SUOX Biomarker Biochemical recurrence Oxidative phosphorylation 

Notes

Compliance with ethical standards

Conflict of interest

All authors have declared that they have no conflicts of interest.

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Copyright information

© The Japanese Society for Clinical Molecular Morphology 2019

Authors and Affiliations

  • Hirofumi Kurose
    • 1
    • 2
  • Yoshiki Naito
    • 1
    • 3
    Email author return OK on get
  • Jun Akiba
    • 3
  • Reiichiro Kondo
    • 1
  • Sachiko Ogasawara
    • 1
  • Hironori Kusano
    • 1
  • Sakiko Sanada
    • 1
  • Hideyuki Abe
    • 3
  • Tatsuyuki Kakuma
    • 4
  • Kosuke Ueda
    • 2
  • Tsukasa Igawa
    • 2
  • Hirohisa Yano
    • 1
  1. 1.Department of PathologyKurume University School of MedicineKurumeJapan
  2. 2.Department of UrologyKurume University School of MedicineKurumeJapan
  3. 3.Department of Diagnostic PathologyKurume University HospitalKurumeJapan
  4. 4.Biostatistics CenterKurume University School of MedicineKurumeJapan

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