Association of Helicobacter pylori with oral potentially malignant disorders and oral squamous cell carcinoma—a systematic review and meta-analysis
- 57 Downloads
To assess any potential association between Helicobacter pylori and oral squamous cell carcinoma/oral potentially malignant disorders.
Materials and methods
Data mining was done using PubMed, Cochrane Library, and SCOPUS databases. The search included articles published up to May 2019. Newcastle-Ottawa scale was used to score the quality of the included articles. Data including the type of study, the sample population, the type of oral lesion, and the resulting statistical data were extracted.
Out of 131 screened articles, only 15 articles fulfilled the eligibility criteria. Among the 15 studies, 9 focused on oral squamous cell carcinoma and 6 focused on oral potentially malignant disorders. Eight out of the 9 oral squamous cell carcinoma studies were included in the meta-analysis. Forest plot was generated using the odds ratio and confidence intervals calculated for each of the included studies. Due to the lack of sufficient studies, the meta-analysis was not performed for oral potentially malignant disorders.
Due to the contradictory results of the included studies, it was not possible to make any conclusive statement on the potential association of H. pylori with oral squamous cell carcinoma. The variations in the methodology, especially the differences in the sensitivity/specificity of the diagnostic modalities could be the cause for differential results.
Although the association of H. pylori with oral squamous cell carcinoma could not be confirmed, it is vital to reduce the excess oral microbial load, especially in patients exhibiting oral mucosal changes with no history of associated risk factors.
KeywordsH. pylori Oral potentially malignant disorders Oral squamous cell carcinoma
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
For this type of study, formal consent is not required.
- 5.Sokic-Milutinovic A, Popovic D, Alempijevic T, Dragasevic S, Lukic S, Pavlovic-Markovic A (2014) Helicobacter pylori infection and gastric cancer — is eradication enough to prevent gastric cancer. In: Roesler B (ed) Trends in Helicobacter pylori infection. In Tech, Rijeka, pp 155–173Google Scholar
- 16.Zenouz AT, Mehdipour M, Heydarlou MJ, Gholizadeh N (2010) Relationship between Lichen planus and Helicobacter pylori infection. J Dent Res Dent Clin Dent Prospect 4(1):17–20Google Scholar
- 17.Chen M, Chen J, Yang Y, Cheng L, Wu HT (2018) Possible association between Helicobacter pylori infection and vocal fold leukoplakia. Head Neck:1–10Google Scholar
- 18.Veiga N, Pereira C, Resende C, Amaral O, Ferreira M, Nelas P, Chaves C, Duarte J, Cirnes L, Machado JC, Ferreira P, Correia IJ (2015) Oral and gastric Helicobacter pylori: effects and associations. PLoS One 10(5):e0126923. https://doi.org/10.1371/journal.pone.0126923 CrossRefPubMedPubMedCentralGoogle Scholar
- 19.Viganò L, Cinzia C, Oliveira A, Guerrieri P (2018) Helicobacter pylori: is there an association with oral pathologies? A Traditional Review. Acta Sci Microbiol:32–39Google Scholar
- 25.Ravali CT (2017) Association of Helicobacter pylori in oral cancer patients. Int J Appl Dent Sci 3(3):185–192Google Scholar
- 27.Irani S, Esfahani AM, Zerehpoush FB (2013) Detection of Helicobacter pylori in oral lesions. J Dent Res Dent Clin Dent Prospect 7(4):230–237Google Scholar
- 28.Gupta AA, Kheur S, Mamatha GS, Shetty L, Kheur M (2016) Helicobacter pylori as a risk indicator of oral squamous cell carcinoma – a PCR based study. Int Jr Current Research 8(7):34109–34119Google Scholar