Advertisement

Does oral dryness influence pressure pain sensitivity in the oral mucosa of removable denture wearers?

  • Yuka Inamochi
  • Kenji FuekiEmail author
  • Yusuke Matsuyama
  • Eiko Yoshida-Kohno
  • Takeo Fujiwara
  • Noriyuki Wakabayashi
Original Article
  • 17 Downloads

Abstract

Objective

This study aimed to determine if oral dryness is associated with oral pain sensitivity in removable denture wearers.

Materials and methods

The pressure pain threshold (PPT) in the mucosa at the midline between the central incisors in the maxilla and mandible was evaluated in 333 removable denture wearers (mean age 71.2 years, male 33.3%). The frequency of oral dryness and severity of anxiety were evaluated using self-reported questionnaires. Multilevel analyses considering the correlated data structure (jaws nested within individual) adjusted for age, sex, number of missing teeth, anxiety level, smoking status, and systemic diseases were performed to examine the association between PPT and oral dryness. Further subgroup analysis stratified by number of missing teeth was performed.

Results

Oral dryness was present in 122 (21.6%) of 566 jaws in 73 (21.9%) of the 333 subjects. The mean (standard deviation) of the log PPT was 2.00 (0.26) in the subjects who perceived oral dryness and 2.04 (0.22) in those who did not. Oral dryness was associated with a lower log PPT, but the relationship was not significant (coefficient − 0.017; 95% confidence interval − 0.071, 0.038). Subjects with oral dryness and edentulous oral mucosa had a significantly lower PPT (coefficient − 0.145; 95% confidence interval − 0.283, − 0.006) than their partially dentate counterparts.

Conclusion

There was a significant association of oral dryness with increased pressure pain sensitivity in the oral mucosa only in jaws with complete dentures.

Clinical relevance

The approach to oral dryness could contribute to reduction of oral pain sensitivity.

Keywords

Oral dryness Pressure pain threshold Removable denture Oral pain sensitivity 

Abbreviations

CI

Confidence interval

PPT

Pressure pain threshold

Notes

Acknowledgments

We are most grateful to Dr. Hayato Kumagai for his collaboration in this research.

Funding

This study was supported by a Grant-in-Aid for Young Scientists (B) (No. 25861826), a Grant-in-Aid for Scientific Research (C) (No. 15K11150), and a Grant-in-Aid for Young Scientists (No. 18K17137) from the Japan Society for the Promotion of Science.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board of Tokyo Medical and Dental University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Brunello DL, Mandikos MN (1998) Construction faults, age, gender, and relative medical health: factors associated with complaints in complete denture patients. J Prosthet Dent 79:545–554.  https://doi.org/10.1016/S0022-3913(98)70176-3 CrossRefPubMedGoogle Scholar
  2. 2.
    Kumagai H, Fueki K, Yoshida-Kohno E, Wakabayashi N (2016) Factors associated with mucosal pain in patients with partial removable dental prostheses. J Oral Rehabil 43:683–691.  https://doi.org/10.1111/joor.12417 CrossRefPubMedGoogle Scholar
  3. 3.
    Ogawa T, Tanaka M, Ogimoto T, Okushi N, Koyano K, Takeuchi K (2004) Mapping, profiling and clustering of pressure pain threshold (PPT) in edentulous oral mucosa. J Dent 32:219–228.  https://doi.org/10.1016/j.jdent.2003.11.001 CrossRefPubMedGoogle Scholar
  4. 4.
    Tanaka M, Ogimoto T, Koyano K, Ogawa T (2004) Denture wearing and strong bite force reduce pressure pain threshold of edentulous oral mucosa. J Oral Rehabil 31:873–878.  https://doi.org/10.1111/j.1365-2842.2004.01321.x CrossRefPubMedGoogle Scholar
  5. 5.
    Isobe A, Sato Y, Kitagawa N, Shimodaira O, Hara S, Takeuchi S (2013) Influence of denture supporting tissue properties on pressure-pain threshold--measurement in dentate subjects. J Prosthodont Res 57:275–283.  https://doi.org/10.1016/j.jpor.2013.07.002 CrossRefPubMedGoogle Scholar
  6. 6.
    Chen J, Ahmad R, Li W, Swain M, Li Q (2015) Biomechanics of oral mucosa. J R Soc Interface 12:20150325.  https://doi.org/10.1098/rsif.2015.0325 CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Klages U, Kianifard S, Ulusoy O, Wehrbein H (2006) Anxiety sensitivity as predictor of pain in patients undergoing restorative dental procedures. Community Dent Oral Epidemiol 34:139–145.  https://doi.org/10.1111/j.1600-0528.2006.00265.x CrossRefPubMedGoogle Scholar
  8. 8.
    Arslan A, Orhan K, Canpolat C, Delilbasi C, Dural S (2009) Impact of xerostomia on oral complaints in a group of elderly Turkish removable denture wearers. Arch Gerontol Geriatr 49:263–267.  https://doi.org/10.1016/j.archger.2008.09.008 CrossRefPubMedGoogle Scholar
  9. 9.
    Ikebe K, Morii K, Kashiwagi J, Nokubi T, Ettinger RL (2005) Impact of dry mouth on oral symptoms and function in removable denture wearers in Japan. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:704–710.  https://doi.org/10.1016/j.tripleo.2004.09.008 CrossRefPubMedGoogle Scholar
  10. 10.
    Han P, Suarez-Durall P, Mulligan R (2015) Dry mouth: a critical topic for older adult patients. J Prosthodont Res 59:6–19.  https://doi.org/10.1016/j.jpor.2014.11.001 CrossRefPubMedGoogle Scholar
  11. 11.
    Acharya S, Hägglin C, Jontell M, Wenneberg B, Ekström J, Carlén A (2018) Saliva on the oral mucosa and whole saliva in women diagnosed with burning mouth syndrome. Oral Dis 24:1468–1476.  https://doi.org/10.1111/odi.12918 CrossRefPubMedGoogle Scholar
  12. 12.
    Acharya S, Carlén A, Wenneberg B, Jontell M, Hägglin C (2018) Clinical characterization of women with burning mouth syndrome in a case-control study. Acta Odontol Scand 76:279–286.  https://doi.org/10.1080/00016357.2017.142022 CrossRefPubMedGoogle Scholar
  13. 13.
    Jääskeläinen SK, Woda A (2017) Burning mouth syndrome. Cephalalgia 37:627–647.  https://doi.org/10.1177/0333102417694883 CrossRefPubMedGoogle Scholar
  14. 14.
    Ogimoto T, Ogawa T, Sumiyoshi K, Matsuka Y, Koyano K (2002) Pressure-pain threshold determination in the oral mucosa: validity and reliability. J Oral Rehabil 29:620–626.  https://doi.org/10.1046/j.1365-2842.2002.00874.x CrossRefPubMedGoogle Scholar
  15. 15.
    Ikebe K, Matsuda K, Morii K, Wada M, Hazeyama T, Nokubi T, Ettinger RL (2007) Impact of dry mouth and hyposalivation on oral health-related quality of life of elderly Japanese. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:216–222.  https://doi.org/10.1016/j.tripleo.2005.12.001 CrossRefPubMedGoogle Scholar
  16. 16.
    Carramolino-Cuéllar E, Lauritano D, Silvestre FJ, Carinci F, Lucchese A, Silvestre-Rangil J (2018) Salivary flow and xerostomia in patients with type 2 diabetes. J Oral Pathol Med 47:526–530.  https://doi.org/10.1111/jop.12712 CrossRefPubMedGoogle Scholar
  17. 17.
    Liu B, Dion MR, Jurasic MM, Gibson G, Jones JA (2012) Xerostomia and salivary hypofunction in vulnerable elders: prevalence and etiology. Oral Surg Oral Med Oral Pathol Oral Radiol 114:52–60.  https://doi.org/10.1016/j.oooo.2011.11.014 CrossRefPubMedGoogle Scholar
  18. 18.
    Collin HL, Niskanen L, Uusitupa M, Töyry J, Collin P, Koivisto AM, Viinamäki H, Meurman JH (2000) Oral symptoms and signs in elderly patients with type 2 diabetes mellitus. A focus on diabetic neuropathy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90:299–305.  https://doi.org/10.1067/moe.2000.107536 CrossRefPubMedGoogle Scholar
  19. 19.
    Lin CS, Wu SY, Yi CA (2017) Association between anxiety and pain in dental treatment: a systematic review and meta-analysis. J Dent Res 96:153–162.  https://doi.org/10.1177/0022034516678168 CrossRefPubMedGoogle Scholar
  20. 20.
    Gholami N, Hosseini Sabzvari B, Razzaghi A, Salah S (2017) Effect of stress, anxiety and depression on unstimulated salivary flow rate and xerostomia. J Dent Res Dent Clin Dent Prospects 11:247–252.  https://doi.org/10.15171/joddd.2017.043 CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Nakazato K, Mizuguchi T (1982) How to use STAI. Kyoto, SankyoboGoogle Scholar
  22. 22.
    Hopcraft MS, Tan C (2010) Xerostomia: an update for clinicians. Aust Dent J 55:238–244.  https://doi.org/10.1111/j.1834-7819.2010.01229 CrossRefPubMedGoogle Scholar
  23. 23.
    Teranaka S, Shibaji T, Minakuchi S, Uematsu H (2008) Age-related changes in oral mechanosensitivity of symptom-free subjects. J Med Dent Sci 55:61–69.  https://doi.org/10.11480/jmds.550108 CrossRefPubMedGoogle Scholar
  24. 24.
    Lynge Pedersen AM, Nauntofte B, Smidt D, Torpet LA (2015) Oral mucosal lesions in older people: relation to salivary secretion, systemic diseases and medications. Oral Dis 21:721–729.  https://doi.org/10.1111/odi.12337 CrossRefPubMedGoogle Scholar
  25. 25.
    Niedermeier WH, Krämer R (1992) Salivary secretion and denture retention. J Prosthet Dent 67:211–216.  https://doi.org/10.1016/0022-3913(92)90455-J CrossRefPubMedGoogle Scholar
  26. 26.
    Awad MA, Rashid F, Feine JS, Overdenture Effectiveness Study Team Consortium (2014) The effect of mandibular 2-implant overdentures on oral health-related quality of life: an international multicentre study. Clin Oral Implants Res 25:46–51.  https://doi.org/10.1111/clr.12205 CrossRefPubMedGoogle Scholar
  27. 27.
    Ikebe K, Morii K, Matsuda K, Hata K, Nokubi T (2006) Association of candidal activity with denture use and salivary flow in symptom-free adults over 60 years. J Oral Rehabil 33:36–42.  https://doi.org/10.1111/j.1365-2842.2006.01527.x CrossRefPubMedGoogle Scholar
  28. 28.
    Bogucki ZA (2013) Clinical aspects of the use of dental adhesive materials in patients with chronic xerostomia. Gerodontology 30:162–166.  https://doi.org/10.1111/j.1741-2358.2012.00659 CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Removable Partial Prosthodontics, Division of Oral Health Sciences, Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Department of Global Health PromotionTokyo Medical and Dental UniversityTokyoJapan

Personalised recommendations