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CD146 expression in oral lichen planus and oral cancer

  • Sarinthon Pariyawathee
  • Ekarat Phattarataratip
  • Kobkan ThongprasomEmail author
Original Article
  • 29 Downloads

Abstract

Objective

To examine the CD146/METCAM expression on keratinocytes in normal oral mucosa (NOM), oral lichen planus (OLP), oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC).

Subjects and methods

Immunohistochemical examination of CD146 was performed on 80 specimens, divided into 20 cases from each group. The number of CD146+ keratinocytes was quantitatively assessed together with the staining intensity.

Results

The mean percentage of CD146+ keratinocytes was 19.04+15.32, 59.40+24.48, 60.04+28.87, and 22.13+21.03 in NOM, OLP, OED, and OSCC, respectively. The mean percentages of CD146+ keratinocytes in OLP and OED were significantly higher than those of NOM and OSCC (p≤0.001). Most OED (55%) and OLP (60%) showed strong and moderate staining intensity, respectively, while NOM (50%) and OSCC (45%) predominantly expressed CD146 at mild intensity.

Conclusions

This is the first study to examine CD146 expression in OLP and OED. CD146 is upregulated in OLP and OED but downregulated in OSCC. The alteration in CD146 may be involved in the immunoregulatory response of OLP and the early event of oral carcinogenesis. The loss of this protein may underlie the progression of OED into invasive OSCC.

Clinical relevance

Overexpression of CD146 protein may play a role in the pathophysiology of OLP and OED.

Keywords

CD146 METCAM Oral epithelial dysplasia Oral lichen planus Oral squamous cell carcinoma 

Notes

Acknowledgments

We thank Mr. Koson Intarasut, Institute of Pathology, Bangkok, Thailand, for immunohistochemistry technical assistant, Dr. Kevin Tompkins for critical review of this manuscript, and Assistant Professor Dr. Soranun Chantarangsu for statistical analysis. Our thanks also go to the Oral Medicine and Oral Pathology staff at the Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand, for their assistance. We thank the Research Unit in Oral Diseases, Chulalongkorn University for long-term support.

Funding

This research was supported by the Faculty Research Grant (DRF 60020), Faculty of Dentistry, Chulalongkorn University 2017 and the 90 year of Chulalongkorn University, Rachadapiseksoompoch grant 2017.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The Ethics Committee of Chulalongkorn University, Faculty of Dentistry, approved this study protocol.

Informed consent

Informed consent was obtained from all individual participants included in this study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Oral Medicine Department, Faculty of DentistryChulalongkorn UniversityBangkokThailand
  2. 2.Oral Pathology Department, Faculty of DentistryChulalongkorn UniversityBangkokThailand

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