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Clinical Oral Investigations

, Volume 23, Issue 11, pp 4083–4097 | Cite as

Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with corticotomy?

  • Ewerton Zaniboni
  • Leonardo Bagne
  • Thaís Camargo
  • Maria Esméria Corezola do Amaral
  • Maira Felonato
  • Thiago Antônio Moretti de Andrade
  • Gláucia Maria Tech dos Santos
  • Guilherme Ferreira Caetano
  • Marcelo Augusto Marreto Esquisatto
  • Milton Santamaria JrEmail author
  • Fernanda Aparecida Sampaio Mendonça
Original Article

Abstract

Objectives

Evaluate the bone remodeling during orthodontic movement with corticotomy when submitted to low-intensity electrical stimulation application (microcurrent—MC) and low-level laser therapy (LLLT).

Material and methods

One hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/corticotomy; (Cort-L) tooth movement/corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/corticotomy and laser/microcurrent alternated. Inflammation, angiogenesis, and osteogenesis were evaluated in the periodontal ligament (PDL) and alveolar bone on the 7th, 14th, and 21st days of orthodontic movement.

Results

The quantification of inflammatory infiltrate, angiogenesis and expression of TGF-β1, VEGF, and collagen type I were favorably modulated by the application of therapies such as low-level laser therapy (LLLT), MC, or both combined. However, electrical stimulation increased fibroblasts, osteoclasts and RANK numbers, birefringent collagen fiber organization, and BMP-7 and IL-6 expression.

Conclusions

Low-level laser therapy (LLLT) and MC application both improved the process of bone remodeling during orthodontic treatment with corticotomy. Still, electrical current therapy promoted a more effective tooth displacement but presented expected root resorption similar to all experimental treatments.

Clinical relevance

It is important to know the effects of minimally invasive therapies on cellular and molecular elements involved in the bone remodeling of orthodontic treatment associated with corticotomy surgery, in order to reduce the adverse effects in the use of this technique and to establish a safer clinical routine.

Keywords

Electrical stimulation Phototherapy Osteotomy Corticotomy Orthodontic movement Osteogenesis 

Notes

Funding

The work was supported by the Heminio Ometto Foundation.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed and were in accordance with the ethical standards of the Research Ethics Committee of Herminio Ometto University Center (Permit no. 020/2015).

Informed consent

For this type of study, formal consent is not required.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Ewerton Zaniboni
    • 1
  • Leonardo Bagne
    • 1
  • Thaís Camargo
    • 1
  • Maria Esméria Corezola do Amaral
    • 1
  • Maira Felonato
    • 1
  • Thiago Antônio Moretti de Andrade
    • 1
  • Gláucia Maria Tech dos Santos
    • 1
  • Guilherme Ferreira Caetano
    • 1
  • Marcelo Augusto Marreto Esquisatto
    • 1
  • Milton Santamaria Jr
    • 1
    • 2
    Email author
  • Fernanda Aparecida Sampaio Mendonça
    • 1
  1. 1.Graduate Program of Biomedical Sciences, Herminio Ometto University CenterUNIARARASArarasBrazil
  2. 2.Graduate Program of Orthodontics, Herminio Ometto University CenterUNIARARASArarasBrazil

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