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Clinical Oral Investigations

, Volume 23, Issue 11, pp 4019–4027 | Cite as

Periradicular inflammatory response, bone resorption, and cementum repair after sealing of furcation perforation with mineral trioxide aggregate (MTA Angelus™) or Biodentine™

  • Magda de Sousa Reis
  • Roberta Kochenborger ScarparoEmail author
  • Liviu Steier
  • José Antônio Poli de Figueiredo
Original Article

Abstract

Objective

This study assessed tissue responses after furcation perforation and immediate sealing with either Biodentine™ or MTA Angelus™.

Material and methods

Sixty male Wistar rats were used (n = 6 per group/period). The mandibular first molars had the furcation mechanically exposed and sealed with either MTA or Biodentine™ and restored with silver amalgam. In an additional test group, teeth were sealed only with Biodentine™. Furcation sealing with gutta-percha and silver amalgam restoration served as positive control, and healthy untreated teeth were the negative control. Histological evaluation was performed after 14 or 21 days. Kruskal-Wallis and Dunn’s post hoc tests were performed to analyze the extent and intensity of tissue inflammation, bone resorption, and cementum repair (p < 0.05).

Results

Biodentine™ and MTA presented satisfactory results, showing a milder inflammatory response when compared to the control, regardless of the material used for coronal sealing and of the experimental period evaluated (p < 0.0001). All test groups showed less bone resorption than the positive control after 21 days (p < 0.05), and such differences were more pronounced in teeth restored with silver amalgam. Cementum repair was performed in 30% of MTA and Biodentine™ samples but not carried out in any positive control specimen.

Conclusions

Biodentine™ and MTA promoted similar responses when used to seal furcation perforations and should therefore be regarded as a promising alternative.

Clinical relevance

Knowledge about tissue responses to restorative materials is essential for improving root perforation sealing protocols. The present results showed that both Biodentine™ and MTA promoted appropriate periradicular tissue reactions in a preclinical test for evaluating furcation perforation treatments.

Keywords

Furcation perforation Repair Biodentine Mineral trioxide aggregate 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This study was approved by the Animal Care and Use Committee of the Pontifical Catholic University of Rio Grande do Sul, Brazil (Process: 12/00320).

Informed consent

This article does not contain any studies with human participants. Informed consent is not required.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of DentistryUniversity of Santa Cruz do SulSanta Cruz do SulBrazil
  2. 2.School of DentistryFederal University of Rio Grande do SulPorto Alegre, RSBrazil
  3. 3.Department of DentistryFederal University of Rio Grande do SulPorto Alegre, RSBrazil
  4. 4.Department of Oral BiologyFederal University of Rio Grande do SulPorto AlegreBrazil

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