Alveolar bone preservation by a hydroxyapatite/collagen composite material after tooth extraction
- 97 Downloads
The aim of this study was to assess the effectiveness of a hydroxyapatite/collagen composite material (HAp/Col) for preservation of alveolar bone after tooth extraction.
Materials and methods
HAp/Col was applied to the alveolus bone ridge preservation after tooth extraction, because of subsequent dental implant placement in 35 regions of 24 patients (mean age, 59.3 years; range, 25–81 years). Cone beam computed tomography was used to assess changes in alveolar bone at the extraction site before and at 3 months (mean, 13.7 weeks; range, 10–17 weeks) after tooth extraction. Changes in height and width of the alveolar bone were measured to evaluate bone reduction after surgery. Bone biopsy was performed at 11 regions of dental implant placement to observe bone regeneration and remaining material in the extraction socket.
The alveolar bone height was decreased by 0.00 ± 2.44 mm at the buccal side and 0.35 ± 1.73 mm at the lingual side, while the width was decreased by 1.02 ± 1.64 mm at 3 months after surgery. The middle of the socket floor was elevated by 5.71 ± 3.45 mm at 3 months after surgery. Bone biopsy specimens revealed no remaining implanted material, and approximately 49.79 ± 14.41% of the specimens were occupied by bone tissue.
According to the result of this study, HAp/Col is a reliable material to presearve alveolar bone after tooth extraction.
HAp/Col contributes dental implant treatment due to maintain the alveolar bone after tooth extraction.
KeywordsHydroxyapatite/collagen composite material Alveolar bone preservation Bone height Bone width
We thank all staff of the Center of Oral and Maxillofacial Implants at Nagasaki University Hospital and the Department of Regenerative Oral Surgery at the Graduate School of Nagasaki University for surgical assistance. We also appreciate Prof. Takashi Sawase for critical reading of the manuscript.
Compliance with ethical standards
Conflict of interest
HAp/Col which was used in this study was provided from HOYA Technosurgical.
This study was approved by the Clinical Research Ethics Committee of Nagasaki University Hospital (Approval No. 15012684).
All patients provided sufficient informed consent and agreed to participate in this study.
- 2.Aimetti M, Romano F, Griga FB, Godio L (2009) Clinical histologic healing of human extraction sockets filled with calcium sulfate. Int J Oral Maxillofac Implants 24:901–909Google Scholar
- 6.Barone A, Toti P, Quaranta A, Alfonsi F, Cucchi A, Negri B, Di Felice R, Marchionni S, Calvo-Guirado JL, Nannmark U (2017) Clinical and histological changes after ridge preservation with two xenografts: preliminary results from a multicenter randomized controlled clinical trial. J Clin Periodontol 44:204–214CrossRefGoogle Scholar
- 8.Hebbers S, Al-Chawaf B, Hildebrand D, Nelson JJ, Nelson K (2008) Histomorphometric analysis of extraction sockets augmented with Bio-Oss collagen after a 6-week healing period: a prospective study. Clin Oral Implants Res 29:1219–1225Google Scholar
- 9.Iasella JM, Greenwell H, Miller RL, Driskio C, Bohra AA, Scheetz P (2003) Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: a clinical and histological study in humans. J Periodontol 74:990–999CrossRefGoogle Scholar
- 12.Kawasaki Y, Sotome S, Yoshii T, Torigoe I, Maehara H, Sugata Y, Hirano M, Mochizuki N, Shinomiya K, Okawa A (2000) Effect of gamma-ray irradiation on mechanical properties, osteoconductivity, and absorption of porous hydroxyapatite/collagen. J Biomed Mater Res Part B: Appl Biomater 92B:161–167CrossRefGoogle Scholar
- 15.Kitsugi D, Kodama T, Sugiyama T, Ikai H, Tsutsumi K, Fushimi H, Hori T (1997) The effect of tooth extraction alveolus healing by atelo-collagen sponge implantation. J I Oral Implantol 10:444–453 in JapaneseGoogle Scholar
- 21.Scropp L, Wenzel A, Kostopoulos L, Karring T (2003) Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent 23:313–323Google Scholar
- 23.Sotome S, Ae K, Matsumoto S, Arai Y, Manabe J, Koyanagi H, Yoshii T, Okawa A (2015) Porous hydroxyapatite/collagen composite. Clin Orthoped Surg 50:959–966 in JapaneseGoogle Scholar