Alveolar bone preservation by a hydroxyapatite/collagen composite material after tooth extraction

  • Seigo OhbaEmail author
  • Yoshinori Sumita
  • Yuya Nakatani
  • Sawako Noda
  • Izumi Asahina
Original Article



The aim of this study was to assess the effectiveness of a hydroxyapatite/collagen composite material (HAp/Col) for preservation of alveolar bone after tooth extraction.

Materials and methods

HAp/Col was applied to the alveolus bone ridge preservation after tooth extraction, because of subsequent dental implant placement in 35 regions of 24 patients (mean age, 59.3 years; range, 25–81 years). Cone beam computed tomography was used to assess changes in alveolar bone at the extraction site before and at 3 months (mean, 13.7 weeks; range, 10–17 weeks) after tooth extraction. Changes in height and width of the alveolar bone were measured to evaluate bone reduction after surgery. Bone biopsy was performed at 11 regions of dental implant placement to observe bone regeneration and remaining material in the extraction socket.


The alveolar bone height was decreased by 0.00 ± 2.44 mm at the buccal side and 0.35 ± 1.73 mm at the lingual side, while the width was decreased by 1.02 ± 1.64 mm at 3 months after surgery. The middle of the socket floor was elevated by 5.71 ± 3.45 mm at 3 months after surgery. Bone biopsy specimens revealed no remaining implanted material, and approximately 49.79 ± 14.41% of the specimens were occupied by bone tissue.


According to the result of this study, HAp/Col is a reliable material to presearve alveolar bone after tooth extraction.

Clinical relevance

HAp/Col contributes dental implant treatment due to maintain the alveolar bone after tooth extraction.


Hydroxyapatite/collagen composite material Alveolar bone preservation Bone height Bone width 



We thank all staff of the Center of Oral and Maxillofacial Implants at Nagasaki University Hospital and the Department of Regenerative Oral Surgery at the Graduate School of Nagasaki University for surgical assistance. We also appreciate Prof. Takashi Sawase for critical reading of the manuscript.

Compliance with ethical standards

Conflict of interest

HAp/Col which was used in this study was provided from HOYA Technosurgical.

Ethical approval

This study was approved by the Clinical Research Ethics Committee of Nagasaki University Hospital (Approval No. 15012684).

Informed consent

All patients provided sufficient informed consent and agreed to participate in this study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Seigo Ohba
    • 1
    • 2
    Email author
  • Yoshinori Sumita
    • 2
    • 3
  • Yuya Nakatani
    • 1
    • 2
  • Sawako Noda
    • 1
    • 2
  • Izumi Asahina
    • 1
    • 2
  1. 1.Department of Regenerative Oral Surgery, Institute of Biomedical SciencesNagasaki UniversityNagasakiJapan
  2. 2.Center of Oral and Maxillofacial ImplantsNagasaki University HospitalNagasakiJapan
  3. 3.Basic and Translational Research Center for Hard Tissue DiseaseNagasaki UniversityNagasakiJapan

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