Salivary adiponectin, but not adenosine deaminase, correlates with clinical signs in women with Sjögren’s syndrome: a pilot study
To evaluate salivary adiponectin and adenosine deaminase (ADA) in women suffering from Sjögren’s syndrome (SS).
Salivary adiponectin and ADA were measured in patients with SS (n = 17) and compared to their values in healthy controls (n = 13) and patients suffering from drug-induced xerostomia (non-SS sicca group; n = 19). A clinical history was made for each patient, patients were examined clinically, and xerostomia inventory (XI) was performed.
Salivary adiponectin corrected by total protein was higher in patients with SS than in healthy individuals (P < 0.05) or patients with non-SS sicca (P < 0.01) and correlated with XI (r = 0.555; P < 0.05). Salivary ADA was higher in patients with SS and non-SS sicca compared to controls (P < 0.05 in both cases).
The results of the present study indicate that adiponectin and ADA are increased in the saliva of patients with SS.
Salivary adiponectin corrected by total protein can be a potential biomarker of SS.
KeywordsAdiponectin Adenosine deaminase Biomarker Clinical signs Xerostomia Saliva
AT was financially supported by the Program “Juan de la Cierva Incorporacion” of “Ministerio de Economia y Competitividad,” Spain, through a post-doctoral grant.
AT, PLJ, FT, and SMS designed the study; PLJ, FP, and CZ collected the samples; AT, FT, and SMS analysed the samples; AT, PLJ, FT, and SMS analysed the data; AT, PLJ, FT, and SMS drafted, revised, and approved the manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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