Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis

  • Raluca Cosgarea
  • Roxana Tristiu
  • Raluca Bianca Dumitru
  • Nicole Birgit Arweiler
  • Simona Rednic
  • Cristina Ioana Sirbu
  • Liana Lascu
  • Anton Sculean
  • Sigrun Eick
Original Article

Abstract

Objectives

To compare the effect of non-surgical periodontal therapy on clinical and inflammatory parameters in patients with moderate to severe chronic periodontitis (CP) and rheumatoid arthritis (RA) (RA-CP) with that in CP patients without RA.

Material and methods

Eighteen patients with RA-CP and 18 systemically healthy patients with CP were treated with scaling and root planing (SRP) within 24 h. At baseline, and at 3 and 6 months after SRP, clinical periodontal parameters, inflammatory markers, and microorganisms in subgingival biofilm were assessed. In addition, disease activity markers of RA (DAS28, CRP, ESR) and specific antibodies (RF) were monitored in the RA-CP group.

Results

In both groups, non-surgical therapy yielded to statistically significant improvements in all investigated clinical periodontal variables; in RA patients, a statistically significant decrease in serum-CRP was seen at 3 months. At all time-points, levels of inflammatory markers in GCF were higher in RA-CP than in CP patients. Counts of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola decreased statistically significantly in CP but not in the RA-CP group. Changes of DAS28 correlated positively with those of P. gingivalis and negatively with the plaque index.

Conclusions

Within their limits, the present data suggest that (a) non-surgical periodontal therapy improves periodontal conditions in CP patients with and without RA and (b) in patients with RA, eradication of P. gingivalis in conjunction with a high level oral hygiene may transiently decrease disease activity of RA.

Clinical relevance

In patients with RA and CP, non-surgical periodontal therapy is a relevant modality not only to improve the periodontal condition but also to decrease RA activity.

Keywords

Rheumatoid arthritis Periodontitis Non-surgical periodontal treatment Porphyromonas gingivalis Rheumatoid disease activity 

Notes

Acknowledgements

The authors are grateful to Martin Eckert, Stéphanie Larti, and Anna Magdoń (University of Bern, Department of Periodontology, Laboratory of Oral Microbiology) for technical assistance. The statistical support of Walter B. Bürgin, Dipl. Biomed. Eng. (University Bern, School of Dental Medicine, Ressort Research), is highly appreciated.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards (application—approval no. 580/13.04.2012).

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

784_2018_2420_MOESM1_ESM.pdf (76 kb)
Table S1 (PDF 76 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Raluca Cosgarea
    • 1
    • 2
  • Roxana Tristiu
    • 2
  • Raluca Bianca Dumitru
    • 3
  • Nicole Birgit Arweiler
    • 1
  • Simona Rednic
    • 3
  • Cristina Ioana Sirbu
    • 4
  • Liana Lascu
    • 2
  • Anton Sculean
    • 5
  • Sigrun Eick
    • 5
  1. 1.Clinic of PeriodontologyPhilipps University MarburgMarburgGermany
  2. 2.Clinic of ProsthodonticsUniversity of Medicine and Pharmacy Iuliu HatieganuCluj-NapocaRomania
  3. 3.Clinic of RheumatologyUniversity of Medicine and Pharmacy Iuliu HatieganuCluj-NapocaRomania
  4. 4.Faculty of Economical SciencesUniversity Babes-BolyaiCluj-NapocaRomania
  5. 5.Department of Periodontology, School of Dental MedicineUniversity of BernBernSwitzerland

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