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Structural implications of the paramagnetically shifted NMR signals from pyridine H atoms on synthetic nonheme FeIV=O complexes

  • Waqas Rasheed
  • Ruixi Fan
  • Chase S. Abelson
  • Paul O. Peterson
  • Wei-Min Ching
  • Yisong GuoEmail author
  • Lawrence QueJr.Email author
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Abstract

Oxoiron(IV) motifs are found in important intermediates in many enzymatic cycles that involve oxidations. Over half of the reported synthetic nonheme oxoiron(IV) analogs incorporate heterocyclic donors, with a majority of them comprising pyridines. Herein, we report 1H-NMR studies of oxoiron(IV) complexes containing pyridines that are arranged in different configurations relative to the Fe = O unit and give rise to paramagnetically shifted resonances that differ by as much as 50 ppm. The strong dependence of 1H-NMR shifts on the different configurations and orientation of pyridines relative to the oxoiron(IV) unit demonstrates how unpaired electronic spin density of the iron center affects the chemical shifts of these protons.

Keywords

Nonheme iron Iron(IV)-oxo complexes NMR 

Notes

Acknowledgements

We gratefully acknowledge the support of the U.S. National Science Foundation (Grants CHE-1665391 to L.Q. and CHE-1654060 to Y.G.). The Bruker Avance III HD nanobay 400 MHz spectrometer used in this study was purchased from funds provided by the Office of the Vice President of Research, the College of Science and Engineering, and the Department of Chemistry at the University of Minnesota. The Bruker-AXS D8 Venture Diffractometer was purchased through a grant from NSF/MRI 1229400 and the University of Minnesota. We thank Dr. Letitia Yao for her help with NMR experiments and Dr Victor G. Young and Shuangning Xu for their valuable input on X-ray crystallography. We also thank the Pittsburgh Supercomputing Center for granting us computational resources (CHE180020P to R.F. and Y.G.).

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

775_2019_1672_MOESM1_ESM.pdf (689 kb)
Supplementary material 1 (PDF 690 kb)
775_2019_1672_MOESM2_ESM.pdf (220 kb)
Supplementary material 2 (PDF 219 kb)
775_2019_1672_MOESM3_ESM.pdf (186 kb)
Supplementary material 3 (PDF 186 kb)

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Copyright information

© Society for Biological Inorganic Chemistry (SBIC) 2019

Authors and Affiliations

  1. 1.Department of Chemistry and Center of Metals in BiocatalysisUniversity of Minnesota—Twin CitiesMinneapolisUSA
  2. 2.Department of ChemistryCarnegie Mellon UniversityPittsburghUSA

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