The association between CD31hiEmcnhi endothelial cells and bone mineral density in Chinese women
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Osteoporosis is the most common bone disease in humans. During bone remodeling, specialized blood vessels influenced by the endothelial cells (CD31hiEmcnhi, also called type H cells) are formatted to supply nutrients. Reductions in vascular supply are associated with bone loss resulting in osteoporosis. Therefore, the objective of the present study was to explore the association between the CD31hiEmcnhi endothelial cells and bone mineral density (BMD). In this prospective study, 134 Chinese women were enrolled and examined. BMD was measured by DEXA method while the percentage of CD31hiEmcnhi endothelial cells in the intertrochanteric part was measured by flow cytometry. The percentage of CD31hiEmcnhi endothelial cells in postmenopausal subjects was significantly lower compared with premenopausal women (8.7 ± 4.0% vs 13.2 ± 5.6%, P < 0.01). Meanwhile, the CD31hiEmcnhi endothelial cell levels in osteopenia and osteoporosis were significantly lower compared with subjects with normal BMD (9.84 ± 4.2% in osteopenia and 7.11 ± 3.2% in osteoporosis vs 12.7 ± 5.6% in subjects with normal T score, P < 0.01). Multiple regression analyses showed that the CD31hiEmcnhi endothelial cells level was positively associated with femur neck and total hip BMD, but not with lumbar BMD. Our study suggests a significantly positive association between CD31hiEmcnhi endothelial cells and local BMD in Chinese women. The proportion of CD31hiEmcnhi endothelial cells is a marker of bone quality and represents a potential target for treatment of bone loss.
KeywordsCD31hiEmchhi endothelial cell Type H Bone mineral density Osteoporosis
This work was supported by Hunan Provincial Natural Science Foundation (2016JJ6165).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in this study involving human participants were in accordance with the ethical standards of the Institutional Research and Ethical Committee of Xiangya Hospital and with the 1964 Helsinki Declaration and its later amendments.
All the participants signed a written informed consent and the work was approved by the Ethics and Research Committee of the Xiangya Hospital.
- 4.Liao EY, Zhang ZL, Xia WB, Lin H, Cheng Q, Wang L, Hao YQ, Chen DC, Tang H, Peng YD, You L, He L, Hu ZH, Song CL, Wei F, Wang J, Zhang L (2018) Clinical characteristics associated with bone mineral density improvement after 1-year alendronate/vitamin d3 or calcitriol treatment: exploratory results from a phase 3, randomized, controlled trial on postmenopausal osteoporotic women in China. Medicine 97:e11694. https://doi.org/10.1097/MD.0000000000011694 CrossRefGoogle Scholar
- 5.Lu B, Zhao S, Luo Z, Lin Z, Zhu Y (2018) Compression screws and buttress plate versus compression screws only for Hoffa fracture in Chinese patients: a comparative study. J Int Med Res 300060518798224 https://doi.org/10.1177/0300060518798224
- 6.Long H, Lin Z, Lu B, Zhao R, Sun B, Cheng L, Zhao S, Zhu Y (2016) Percutaneous compression plate versus dynamic hip screw for treatment of intertrochanteric hip fractures: a overview of systematic reviews and update meta-analysis of randomized controlled trials. Int J Surg 33:1–7. https://doi.org/10.1016/j.ijsu.2016.07.005 CrossRefGoogle Scholar
- 7.Oyamada A, Matsumoto Y, Wakata Y, Kimura A, Ikuta K et al (2018) Characteristics of patients with fragility hip fractures in the northern Kyushu district in Japan: a multicenter prospective registry based on an electronic data capture system. J Bone Miner Metab 36:596–604. https://doi.org/10.1007/s00774-017-0869-9 CrossRefGoogle Scholar
- 21.Chapter 1: Definition and classification of CKD (2013). Kidney international supplements 3:19–62 https://doi.org/10.1038/kisup.2012.64
- 24.Siris ES, Adler R, Bilezikian J, Bolognese M, Dawson-Hughes B, Favus MJ, Harris ST, Jan de Beur SM, Khosla S, Lane NE, Lindsay R, Nana AD, Orwoll ES, Saag K, Silverman S, Watts NB (2014) The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group. Osteoporos Int J Establ Result Cooper Between Eur Found Osteoporos Natl Osteoporos Found USA 25:1439–1443. https://doi.org/10.1007/s00198-014-2655-z CrossRefGoogle Scholar
- 27.Bonaccorsi G, Fila E, Messina C, Maietti E, Ulivieri FM, Caudarella R, Greco P, Guglielmi G (2017) Comparison of trabecular bone score and hip structural analysis with FRAX((R)) in postmenopausal women with type 2 diabetes mellitus. Aging Clin Exp Res 29:951–957. https://doi.org/10.1007/s40520-016-0634-2 CrossRefGoogle Scholar
- 30.Prasad M, Reriani M, Khosla S, Gossl M, Lennon R, Gulati R, Prasad A, Lerman LO, Lerman A (2014) Coronary microvascular endothelial dysfunction is an independent predictor of development of osteoporosis in postmenopausal women. Vasc Health Risk Manag 10:533–538. https://doi.org/10.2147/VHRM.S63580 Google Scholar
- 34.Wang J, Gao Y, Cheng P, Li D, Jiang H, Ji C, Zhang S, Shen C, Li J, Song Y, Cao T, Wang C, Yang L, Pei G (2017) CD31hiEmcnhi vessels support new trabecular bone formation at the frontier growth area in the bone defect repair process. Sci Rep 7:4990. https://doi.org/10.1038/s41598-017-04150-5 CrossRefGoogle Scholar