Physical inactivity and vitamin D deficiency in hospitalized elderlies
Serum levels of 25(OH)D, which is known to correlate with systemic nutritional status, is used as an indicator of vitamin D sufficiency in the body. We studied the 25(OH)D status and its background factors including activity of daily living (ADL) in the elderlies hospitalized at the regional core hospital. We also examined whether or not vitamin D deficiency affects ADL among them. This study included newly hospitalized patients aged 65 years or over at Ohchi hospital April to August in 2015. At the time of admission, serum 25(OH)D concentration was measured, and ADL, instrumental ADL (IADL), cognitive function, blood test, nursing care certification were investigated as background factors. Among 209 patients, 25(OH)D was sufficient (> 30 ng/mL) only 14 cases (7%), insufficient (20–30 ng/mL) in 43 cases (20%), and deficient (< 20 ng/mL) in 152 cases (73%). Multivariate analysis showed that low ADL (OR 0.99, 95% CI 0.97–0.99) and low IADL (OR 0.88, 95% CI 0.78–0.99) were independent predictors of 25(OH)D deficiency in two models incorporating ADL and IADL, respectively. Furthermore, low 25(OH)D level was significantly associated with low ADL (OR 0.95, 95% CI 0.91–0.99) and low IADL (OR 0.93, 95% CI 0.88–0.97) scores, suggesting that vitamin D deficiency may affect physical activities. Most hospitalized elderly patients in Japan were deficient for vitamin D. In addition, physical inactivity is strongly associated with vitamin D deficiency.
Keywords25-Hydroxy vitamin D Activity of daily living (ADL) Instrumental ADL (IADL) Elderly
Authors appreciate all the staff of Ohchi Hospital for their skillful assistant. Authors also appreciate the Academic Knowledge Network (AKN) project conducted by Shimane Prefecture, Ohchi Hospital, and Center for community-based healthcare research and education (CoHRE) in Shimane University.
Conceived and designed the experiments: ST SY, collected the data: ST, analyzed the data: ST, supervised: SM AN, wrote the manuscript: ST, and edited the manuscript: SY.
This work is partly supported by subsidy of Shimane Prefecture (to ST) and by JSPS KAKENHI Grant number JP16K13029 (to SY). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Compliance with ethical standards
Conflict of interest
All authors have no conflicts of interest.
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