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Journal of Bone and Mineral Metabolism

, Volume 37, Issue 1, pp 179–184 | Cite as

Association of body mass index and waist circumference with osteocalcin and C-terminal telopeptide in Iranian elderly: results from a cross-sectional study

  • Hamed Kord-Varkaneh
  • Hadith Tangestani
  • Sara Mansouri
  • Abbas Rahimi-Foroushani
  • Sakineh Shab-BidarEmail author
Original Article
  • 126 Downloads

Abstract

There is no agreement on the role of obesity as a protection or unfavorable factor on bone. In the present study, the association of body mass index (BMI) and waist circumference (WC) with osteocalcin, C-terminal telopeptide of type 1 collagen (CTX-I), highly sensitive C-reactive protein (hs-CRP), parathormon (PTH) and 25-hydroxyvitamin D (25(OH)D) in elderly people was investigated. This cross-sectional study was conducted on 178 elderly residents in Tehran, with a mean age of 67.04 (60–83). Serum osteocalcin, hs-CRP, 25(OH) D, PTH and urine CTX-I were measured for all participants. Waist circumference, weight and height were measured and BMI was calculated. Linear regression and Pearson correlation were performed to evaluate the relation of BMI and waist circumference with other variables. A significant inverse association was found between BMI with osteocalcin (β = − 0.171, p = 0.027) after control for covariates. In addition, there were a significant relation of BMI and WC with hs-CRP (β = 0.246, p = 0.002 and β = 0.219, p = 0.006, respectively) and PTH (β = 0.1169, p = 0.040 and β = 0.200, p = 0.018), respectively. The present study did not show a significant relation of BMI and WC with urine CTX-I even after adjustment for potential confounders (β = − 0.143, p = 0.065 and β = − 0.104, p = 0.183, respectively). The present study has concluded that obesity is an undesirable factor for bone metabolism by reducing serum osteocalcin and by increasing hs-CRP and PTH which contribute to bone resorption.

Keywords

Obesity Bone marker Elderly Osteocalcin CTX-I 

Notes

Compliance with ethical standards

Conflict of interest

None of the authors had any personal or financial conflicts of interest.

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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Hamed Kord-Varkaneh
    • 1
  • Hadith Tangestani
    • 1
  • Sara Mansouri
    • 1
  • Abbas Rahimi-Foroushani
    • 2
  • Sakineh Shab-Bidar
    • 1
    Email author
  1. 1.Department of Community Nutrition, School of Nutritional Sciences and DieteticsTehran University of Medical Sciences (TUMS)TehranIran
  2. 2.Department of Occupational Health Engineering, School of Public HealthTehran University of Medical SciencesTehranIran

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