Journal of Bone and Mineral Metabolism

, Volume 37, Issue 1, pp 142–151 | Cite as

Higher serum uric acid is associated with higher lumbar spine bone mineral density in male health-screening examinees: a cross-sectional study

  • Jiwon Hwang
  • Jung Hye Hwang
  • Seungho RyuEmail author
  • Joong Kyong AhnEmail author
Original Article


Bone health has been associated with oxidative stress and antioxidants have received interest to this end. Serum uric acid (SUA), an end product of purine metabolism in humans, has recently shown antioxidant properties regarding bone health, but there are conflicting results. The aim of this study was to investigate the relationship between SUA levels and lumbar spine bone mineral density (BMD) in clinically apparently healthy males aged 40–60 years. We performed a cross-sectional study of 6588 Korean males who completed a health-screening program from January 2011 to December 2014. Of the study participants, the mean age was 48.2 ± 10.7 years. Multiple regression analyses resulted in a significant positive association with lumbar spine BMD across SUA quintiles in a dose–response manner after adjusting for various confounding factors (p = 0.013); for each 1 mg/dl increase of SUA, BMD rose by 0.0054 g/cm2 (p = 0.004). Stratified analyses revealed that this association between SUA and lumbar spine BMD was consistently observed across all clinically relevant subgroups. The present study demonstrated a positive association in males between SUA and lumbar spine BMD, suggesting that SUA could have a profitable effect on bone metabolism.


Uric acid Bone mineral density Bone health DXA Male 



The authors wish to acknowledge Mi-Yeon Lee for expert help in the statistical analysis and Hye Won Min for editing the format.

Compliance with ethical standards

Conflicts of interest

All authors have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional review board and/or national research committee, and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.


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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Internal MedicineNational Police HospitalSeoulRepublic of Korea
  2. 2.Center for Health PromotionSamsung Medical CenterSeoulRepublic of Korea
  3. 3.Department of Occupational and Environmental MedicineKangbuk Samsung Hospital, Sungkyunkwan University School of MedicineSeoulRepublic of Korea
  4. 4.Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulRepublic of Korea
  5. 5.Department of Clinical Research Design and EvaluationSAIHST, Sungkyunkwan UniversitySeoulRepublic of Korea
  6. 6.Division of Rheumatology, Department of Internal Medicine, Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulRepublic of Korea

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