Journal of Bone and Mineral Metabolism

, Volume 37, Issue 1, pp 134–141 | Cite as

Gender differences in anti-osteoporosis drug treatment after osteoporotic fractures

  • Youn Jung
  • Yeonhee Ko
  • Ha Young Kim
  • Yong Chan Ha
  • Young-Kyun Lee
  • Tae-Young Kim
  • Dong-soo Choo
  • Sunmee JangEmail author
Original Article


This study examined differences between men and women in factors affecting anti-osteoporosis drug treatment after osteoporotic fracture. Using a national claims database, we analyzed patients aged 50 years and older who experienced their first osteoporotic fracture between January 1, 2008, and December 31, 2012. We examined whether patients were prescribed anti-osteoporosis drugs within 6 months post-fracture. Factors associated with treatment status were identified using multivariate logistic regression. Among a total of 556,410 patients aged 50 and older, only 37% were prescribed anti-osteoporosis drugs within 6 months post-fracture. Female patients with fractures were more likely to receive pharmacotherapy than male patients (41.7 vs. 19.3%). Older age significantly increased the likelihood of receiving anti-osteoporosis drugs after osteoporotic fracture. For men, the adjusted odds ratio for receiving therapy was greatest in those aged 80 years and older (OR 6.4), and for women, it was largest in those aged 70–79 (OR 3.33). Both men and women were more likely to be prescribed drugs after a spine fracture, with men having significantly greater odds of receiving drug therapy (men, OR 7.1, 95% CI 6.5–7.9; women 4.79, CI 4.63–4.96). Patients with rheumatic disease or other osteoporosis-inducing comorbid disease were more likely to be prescribed anti-osteoporosis drugs. Our findings indicate that a lack of anti-osteoporosis pharmacotherapy after fracture remains a problem in Korea, especially among men, highlighting the need for effective quality improvement interventions to maximize post-fracture treatment rates.


Fractures Gender differences Pharmacotherapy Post-fracture treatment Osteoporosis 



The National Health Insurance Database was made available by the National Health Insurance Service (NHIS) of Korea (NHIS-2017-4-054). The authors would like to thank the NHIS for its cooperation. This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Korea (grant number HI13C1522).

Compliance with ethical standards

Conflict of Interest

All authors have no conflicts of interest.


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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Youn Jung
    • 1
  • Yeonhee Ko
    • 2
  • Ha Young Kim
    • 3
  • Yong Chan Ha
    • 4
  • Young-Kyun Lee
    • 5
  • Tae-Young Kim
    • 6
  • Dong-soo Choo
    • 7
  • Sunmee Jang
    • 8
    Email author
  1. 1.Korea Institute for Health and Social AffairsSejongRepublic of Korea
  2. 2.Gachon University Gil Medical CenterIncheonSouth Korea
  3. 3.Department of Internal MedicineWonkwang University Sanbon HospitalGunpoSouth Korea
  4. 4.Department of Orthopaedic SurgeryChung-Ang University College of MedicineSeoulSouth Korea
  5. 5.Department of Orthopaedic SurgerySeoul National University Bundang HospitalSeongnamSouth Korea
  6. 6.Department of Orthopaedic Surgery, Konkuk University Hospital, School of MedicineKonkuk UniversitySeoulSouth Korea
  7. 7.Big Data Steering DepartmentNational Health Insurance ServiceWonjuSouth Korea
  8. 8.College of Pharmacy and Gachon Institute of Pharmaceutical SciencesGachon UniversityIncheonSouth Korea

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