Journal of Bone and Mineral Metabolism

, Volume 37, Issue 1, pp 118–124 | Cite as

Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery

  • Kentaro YamadaEmail author
  • Shigenobu Satoh
  • Hiroshi Hashizume
  • Noriko Yoshimura
  • Ryohei Kagotani
  • Yuyu Ishimoto
  • Yuichiro Abe
  • Hiromitsu Toyoda
  • Hidetomi Terai
  • Takeshi Masuda
  • Shigeyuki Muraki
  • Hiroaki Nakamura
  • Munehito Yoshida
Original Article


Factors related to the onset and progression of lumbar spinal stenosis (LSS) have not yet been identified. Diffuse idiopathic skeletal hyperostosis (DISH) increases mechanical loading on the non-fused lumbar levels and may therefore lead to LSS. This cross-sectional study aimed to identify associations between LSS and DISH. This study included 2363 consecutive patients undergoing surgery for LSS and 787 general inhabitants without symptoms of LSS as participants of the population-based cohort study, Research on Osteoarthritis/Osteoporosis Against Disability. Standing whole-spine radiographs were used to diagnose DISH based on the criteria proposed by Resnick and Niwayama. The prevalence of DISH showed a significant step-wise increase among asymptomatic inhabitants without radiographic LSS, asymptomatic inhabitants with radiographic LSS, and patients with LSS requiring surgery (14.4, 21.1, and 31.7%, respectively; p < 0.001). The distribution of DISH was similar between the groups, but the lower thoracic and upper-middle lumbar spine regions were more frequently involved in patients with LSS requiring surgery. Multivariate analysis indicated that DISH was an independent associated factor for LSS requiring surgery (adjusted odds ratio 1.65; 95% confidence interval 1.32–2.07) after adjustment for age, sex, body mass index, and diabetes mellitus. Among patients with LSS requiring surgery, a higher occurrence of stenosis at the upper lumbar levels and multi-level stenosis were observed in patients with DISH requiring surgery than in patients without DISH. In conclusion, DISH is independently associated with LSS requiring surgery. The decrease in the lower mobile segments by DISH may increase the onset or severity of LSS.


Diffuse idiopathic skeletal hyperostosis Lumbar spinal stenosis General inhabitants Prevalence Standing whole-spine radiographs 



The authors wish to thank Dr. Shinji Takahashi, MD, PhD, for statistical assistance. The authors also thank Ms. Tomoko Takijiri and other members of the Public Office in Hidakagawa Town, and Ms. Tamako Tsutsumi, Ms. Kanami Maeda, and other members of the Public Office in Taiji Town, for their assistance in locating and scheduling participants for examinations for the Wakayama Spine Study.

Compliance with ethical standards

Conflict of interest

This study was supported by Grants-in-Aid for Scientific Research (B20390182, B23390357, B26860419, C20591737, C20591774, and C26462249), for Young Scientists (A18689031), and for Exploratory Research (19659305) from the Japanese Ministry of Education, Culture, Sports, Science and Technology; H17-Men-eki-009, H18-Choujyu-037, and H20-Choujyu-009 from the Ministry of Health, Labour and Welfare; Research Aid from the Japanese Orthopaedic Association; Grants from the Japanese Orthopaedics and Traumatology Foundation, Inc. (nos. 166 and 256); and a Grant-in-Aid for Scientific Research (C22591639) from the Japanese Society for the Promotion of Science. The sponsors had no role in the study design, data collection, data analysis, data interpretation, or writing of the report. Funding was provided by the Japan Osteoporosis Society and Wakayama Medical Award for Young Researchers.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards in the Wajokai Eniwa Hospital and Wakayama Medical University.

Supplementary material

774_2017_901_MOESM1_ESM.pdf (120 kb)
Supplementary material 1 (PDF 120 kb)


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Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Kentaro Yamada
    • 1
    • 2
    Email author
  • Shigenobu Satoh
    • 1
  • Hiroshi Hashizume
    • 3
  • Noriko Yoshimura
    • 4
  • Ryohei Kagotani
    • 3
  • Yuyu Ishimoto
    • 3
  • Yuichiro Abe
    • 1
  • Hiromitsu Toyoda
    • 2
  • Hidetomi Terai
    • 2
  • Takeshi Masuda
    • 1
  • Shigeyuki Muraki
    • 4
  • Hiroaki Nakamura
    • 2
  • Munehito Yoshida
    • 3
  1. 1.Department of Orthopaedic SurgeryWajokai Eniwa HospitalHokkaidoJapan
  2. 2.Department of Orthopaedic SurgeryOsaka City University Graduate School of MedicineOsakaJapan
  3. 3.Department of Orthopaedic SurgeryWakayama Medical UniversityWakayamaJapan
  4. 4.Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of MedicineThe University of TokyoTokyoJapan

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