Brexanolone and postpartum depression: what does it have to do with GABA?
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Puerperal depression is a form of (major depressive disorder) MDD that is universally recognized. A meta-analysis (O’Hara and Swain 1996) showed a prevalence of 13% with most cases starting in the first 3 months postpartum. Particular at-risk groups include pregnant immigrant women (Zelkowitz et al. 2008), teenage pregnancy (Bayatpour et al. 1992), assisted conception (Hammarberg et al. 2008), and previous stillbirth (Turton et al. 2001) The Edinburgh Postnatal Depression Scale (EPDS) has been developed to detect mothers suffering from postnatal depression in primary healthcare settings (Cox et al. 1987). Exact neurobiology remains elusive. Possibly hormonal (gonadal steroids) fluctuations associated with childbirth induce depression in vulnerable women (Bloch et al. 2000) . Other mechanisms at play include dysregulation of HPA axis already present in pregnancy. A study has showed a direct association between blood levels of CRH in the second trimester and development of postnatal...
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