Archives of Women's Mental Health

, Volume 22, Issue 1, pp 129–132 | Cite as

The association of serum C-reactive protein with the occurrence and course of postpartum depression

  • Emily S. MillerEmail author
  • Denada Hoxha
  • Emily Pinheiro
  • William A. Grobman
  • Katherine L. Wisner
Short Communication


CRP has been positively correlated with depressive symptomatology but this has received less study in postpartum depression (PPD). In this secondary analysis of a trial of PPD treatment, depressive symptoms (Structured Interview Guide for the Hamilton Depression Rating Scale—Atypical Depression Symptoms (SIGH-ADS29)) and serum CRP levels were assessed and associations between CRP and SIGH-ADS29 scores evaluated. The associations between baseline log CRP and depression response and remission were also assessed. Of the 35 women included, neither baseline log CRP nor exit log CRP was significantly associated with SIGH-ADS29 score. Baseline CRP was not associated with response or remission. In this sample of women with PPD, CRP was not associated with depressive symptoms nor response to treatment.


Postpartum depression Inflammation C-reactive protein CRP 



This work was supported by the National Institutes of Health awarded to ESM (5K12HD050121-09).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Emily S. Miller
    • 1
    • 2
    • 3
    Email author
  • Denada Hoxha
    • 4
  • Emily Pinheiro
    • 1
  • William A. Grobman
    • 1
    • 2
  • Katherine L. Wisner
    • 1
    • 3
  1. 1.Feinberg School of MedicineNorthwestern UniversityChicagoUSA
  2. 2.Department of Obstetrics and Gynecology, Division of Maternal Fetal MedicineNorthwestern UniversityChicagoUSA
  3. 3.Department of Psychiatry and Behavioral SciencesNorthwestern UniversityChicagoUSA
  4. 4.Wellsprings Health CliniciansChicagoUSA

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