1H NMR study of the effect of cucurbituril on the aquation of carboplatin in biologically relevant media
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The aquation of carboplatin, a second-generation Pt(II)-based antitumor drug, in two biologically relevant media (PBS buffer solution and RPMI-1640 medium for cell growth) has been studied by means of 1H nuclear magnetic resonance spectroscopy. The effect of the macrocyclic cavitand cucurbituril on the carboplatin aquation rates in these two types of media has also been studied. Although, the cucurbituril does not form stable inclusion complex with carboplatin, it greatly affects the carboplatin aquation rates, presumably, through the two mechanisms: prevention of the carboplatin dimer formation and encapsulation of some components of the medium.
The work was supported by the Russian Foundation for Basic Research (RFBR) grant 18-315-00158 mol_a.
- 21.R. Gust, B. Schnurr, Monatshefte für Chemie/Chem. Mon. 130, 637 (1999)Google Scholar