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Green one-pot synthesis of N-bisphosphonates as antimicrobial and antioxidant agents

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Abstract

A straightforward and greener approach has been developed for the synthesis of novel aminomethylene bisphosphonates by one-pot reaction of diverse aryl/heteroaryl amines with dialkyl phosphite and triethyl orthoformate using CuO nanoparticles as catalyst under microwave irradiation and solvent-free conditions. This is an ecofriendly synthetic approach for swift access to a library of diverse aminomethylene bisphosphonates. All the synthesized new compounds were evaluated for their antimicrobial activity by disc diffusion method and antioxidant activity by DPPH, H2O2, and NO methods. The title compounds exhibited significant antioxidant and considerable antimicrobial activities.

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Acknowledgements

The authors are grateful to Prof. C. Devendranath Reddy, Department of Chemistry, S.V. University, Tirupati, for his helpful discussions. The author T. Sreekanth is thankful to the University Grants Commission (UGC), New Delhi, for providing financial support through Senior Research Fellowship (File no: 21/12/2014(ii)EU-V dated 29/06/15); one of the authors G. Mohan acknowledge DST-PURSE 2nd Phase Programme in S.V. University, Tirupati, funded by DST, New Delhi, India, for providing instrumental analysis and funding through Senior Research Fellowship (File no. 17118-UGC-III(3)/DST-PURSE-2nd phase/2017, dated 23/08/2018). One of the authors S. Santhisudha expresses her sincere thanks to DST, New Delhi, India, for providing financial support through Woman Scientist Scheme-A (WOS-A) (F. no.: SR/WOS-A/CS-104/2018, Dated: 27-09-2019).

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Correspondence to Suresh Reddy Cirandur.

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Tellamekala, S., Gundluru, M., Sudileti, M. et al. Green one-pot synthesis of N-bisphosphonates as antimicrobial and antioxidant agents. Monatsh Chem 151, 251–260 (2020). https://doi.org/10.1007/s00706-020-02551-3

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Keywords

  • Aminomethylene bisphosphonates
  • CuO nanoparticles
  • Solvent free
  • Microwave irradiation
  • Antimicrobial activity
  • Antioxidant activity