Pseudo-three-component synthesis of substituted 1,2,4-triazolo[1,5-a]pyridines

  • Maryam Shokoohian
  • Nourallah HazeriEmail author
  • Malek Taher Maghsoodlou
  • Mojtaba Lashkari
Original Paper


Heterocyclic 1,2,4-triazoles and their derivatives, such as triazolopyridines, have been used as leading components for the synthesis of numerous heterocyclic compounds; and because of their various biological activities, they have a distinct location in pharmaceutical and medicinal chemistry. In this article, we demonstrate a new way of synthesizing 1,2,4-triazolo[1,5-a]pyridine derivatives, as a one-pot pseudo-three-component reaction, via the reaction of pyridine-2-(1H)-one derivatives and 1,4-cyclohexadione in the adjacency of acetic acid both as solvent and an inexpensive and green catalyst at 50 °C. The desired products were synthesized in good yields, and the chemical structure of the synthesized compounds was recognized using 1H and 13C NMR spectra, FT-IR, melting point, mass spectroscopy, and elementary analysis.

Graphic abstract


Green synthesis 1,4-Cyclohexadione 1,2,4-Triazolo[1,5-a]pyridine Pseudo-three-component reaction Pyridine-2-(1H)-one derivatives 



We are grateful to the Research Council of the University of Sistan and Baluchestan for their support of this work.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Maryam Shokoohian
    • 1
  • Nourallah Hazeri
    • 1
    Email author
  • Malek Taher Maghsoodlou
    • 1
  • Mojtaba Lashkari
    • 2
  1. 1.Department of Chemistry, Faculty of ScienceUniversity of Sistan and BaluchestanZahedanIran
  2. 2.Faculty of ScienceVelayat UniversityIranshahrIran

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