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Monatshefte für Chemie - Chemical Monthly

, Volume 150, Issue 9, pp 1723–1730 | Cite as

Reactive carbonyl compounds, carbonyl stress, and neuroinflammation in methyl alcohol intoxication

  • Jiri HlusickaEmail author
  • Tomas Loster
  • Lucie Lischkova
  • Manuela Vaneckova
  • Pavel Diblik
  • Pavel Urban
  • Tomas Navratil
  • Petr Kacer
  • Tereza Kacerova
  • Sergey Zakharov
Original Paper
  • 97 Downloads

Abstract

Methyl alcohol intoxications are characterized by high lethality and high prevalence of serious visual and brain damage in survivors. The mechanisms of toxic brain damage are complex and the role of carbonyl stress has not been studied yet. We measured the acute and follow-up concentrations of reactive carbonyl compounds in patients with acute methyl alcohol intoxication. Blood samples were collected from 28 subjects hospitalized with confirmed methyl alcohol intoxication and from 36 subjects who survived poisoning 2 years after discharge. Serum concentrations of C6–12 reactive aldehydes were measured by liquid chromatography–electrospray ionization–tandem mass spectrometry. The acute concentrations of all measured reactive aldehydes were higher than the follow-up concentrations: 36.4 ± 4.8 vs. 21.6 ± 5.2 ng cm−3 for C6; 38.9 ± 5 vs. 17.0 ± 2.0 ng cm−3 for C7; 18.8 ± 3.9 vs. 4 ± 0 cm−3 for C8; 36.5 ± 3.9 vs. 19.0 ± 3.0 ng cm−3 for C9; 6.1 ± 0.4 vs. 4.0 ± 0.5 ng cm−3 for C10; 13.6 ± 3.0 vs. 3.7 ± 0.6 ng cm−3 for C11; and 7.8 ± 0.4 vs. 4.7 ± 0.4 ng cm−3 for C12 (all p < 0.001). The patients who survived the intoxication had higher concentration of reactive carbonyl compounds than those who died: 38.6 ± 5.9 vs. 28.3 ± 1.7 ng cm−3 for C6 (p = 0.002); 20.7 ± 4.7 vs. 11.8 ± 1.2 ng cm−3 for C8 (p = 0.001); 37.7 ± 4.8 vs. 31.8 ± 3.8 ng cm−3 for C9 (p = 0.042); and 7.9 ± 0.6 vs. 7.3 ± 0.5 ng cm−3 for C12 (p = 0.022). A significant association was present between severity of metabolic acidosis, anion gap, and the acute concentration of measured biomarkers: r = − 0.39; p = 0.046 for C6; r = − 0.42; p = 0.035 for C7; r = − 0.48; p = 0.012 for C8; r = − 0.39; p = 0.046 for C9; and r = − 0.47; p = 0.015 for C11. The acute concentration of C6–C12 reactive aldehydes positively correlated with the acute serum concentration of leukotrienes (all p < 0.05). Acute elevation of serum concentration of reactive carbonyl compounds suggests that carbonyl stress is involved in the mechanisms of leukotriene-mediated neuroinflammatory response to methyl alcohol-induced toxic brain damage.

Graphical abstract

Keywords

Methanol Poisoning Carbonyl stress Markers Neuroinflammation 

Notes

Acknowledgements

This work was supported by the Ministry of Health of the Czech Republic (AZV) under Grant 16-27075A; and under Grant 44/18/D; and by the First Faculty of Medicine, Charles University in Prague under Grant PROGRES Q25; and under Grant PROGRES Q29.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Jiri Hlusicka
    • 1
    • 2
    Email author
  • Tomas Loster
    • 3
  • Lucie Lischkova
    • 1
    • 2
  • Manuela Vaneckova
    • 4
  • Pavel Diblik
    • 5
  • Pavel Urban
    • 2
    • 6
  • Tomas Navratil
    • 7
    • 8
  • Petr Kacer
    • 9
  • Tereza Kacerova
    • 10
  • Sergey Zakharov
    • 1
    • 2
  1. 1.Toxicological Information CentreGeneral University HospitalPragueCzech Republic
  2. 2.Department of Occupational Medicine, First Faculty of MedicineCharles UniversityPragueCzech Republic
  3. 3.Department of Statistics and ProbabilityUniversity of Economics, Faculty of Informatics and StatisticsPragueCzech Republic
  4. 4.Department of Radiology, First Faculty of MedicineCharles University and General University HospitalPragueCzech Republic
  5. 5.Department of Ophthalmology, First Faculty of MedicineCharles University and General University HospitalPragueCzech Republic
  6. 6.Centre for Industrial Hygiene and Occupational MedicineNational Institute of Public HealthPragueCzech Republic
  7. 7.J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of SciencesPragueCzech Republic
  8. 8.Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of MedicineCharles University and General University HospitalPragueCzech Republic
  9. 9.Czech University of Life SciencesPragueCzech Republic
  10. 10.Department of ChemistryUniversity College LondonLondonUK

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