Monatshefte für Chemie - Chemical Monthly

, Volume 150, Issue 9, pp 1711–1714 | Cite as

Intralipid infusion in paediatric patient with quetiapine and lamotrigine intoxication

  • Jozef Klučka
  • Tomáš Juřenčák
  • Martina Kosinová
  • Štourač PetrEmail author
  • Milan Kratochvíl
  • Yvona Sedláčková
  • Navrátil Tomáš
  • Daniela Pelclová
  • Petr Jabandžiev
Original Paper


We present a case of the acute intoxication of a 17-year-old patient after ingestion of 6 g of quetiapine in combination with 1 g of lamotrigine. Due to the severe tachycardia, hypertension, and prolonged QTc without improvement after standard treatment, the patient was treated with Intralipid 20% intravenous infusion recommended by the Toxicologic Information Centre. After lipid infusion, the QTc rapidly normalised and tachycardia resolved to sinus rhythm. The patient was transferred to psychiatry intensive care on the third day after admission.

Graphical abstract


Antipsychotic drug intoxication Life-threatening arrhythmia Lipid resuscitation Paediatric patient 



The article was written with the support of Specific University Research provided by MŠMT (MUNI/A/1111/2018), supported by MH CZ—DRO (FNBr, 65269705), and Progres Q25/LF1 and Q29/LF1.


  1. 1.
    Urban M, Navratil T, Pelclova D (2013) Neuroendocrinol Lett 34:25PubMedGoogle Scholar
  2. 2.
    Urban M, Lesso R, Pelclova D (2016) Basic Clin Pharmacol Toxicol 119:115CrossRefPubMedGoogle Scholar
  3. 3.
    DeVane CL, Nemeroff CB (2001) Clin Pharmacokinet 40:509CrossRefPubMedGoogle Scholar
  4. 4.
    Douglas-Hall P, Dzahini O, Gaughran F, Bile A, Taylor D (2017) Ther Adv Psychopharmacol 1:17CrossRefGoogle Scholar
  5. 5.
    Dickinson DF (2005) Heart 91:1626CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Ghannoum M, Hoffman RS, Gosselin S, Nolin TD, Layergne V, Roberts DM (2018) Kidney Int 94:682CrossRefPubMedGoogle Scholar
  7. 7.
    Neal JM, Barrington MJ, Fettiplace MR, Gitman M, Memtsoudis SG, Mörwald EE, Rubin DS, Weinberg G (2017) Reg Anesth Pain Med 43:113CrossRefGoogle Scholar
  8. 8.
    Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ (1998) Anesthesiology 88:1071CrossRefPubMedGoogle Scholar
  9. 9.
    Muraro L, Longo L, Geraldini F, Bortot A, Paoli A, Boscolo A (2016) J Anesth 30:895CrossRefPubMedGoogle Scholar
  10. 10.
    Bayram B, Kose I, Avci S, Arslan A, Acara C (2015) Pharmacotherapy 35:E149CrossRefPubMedGoogle Scholar
  11. 11.
    Akarca FK, Akceylan E, Kiyan S (2017) Cardiovasc Toxicol 17:482CrossRefGoogle Scholar
  12. 12.
    Otte S, Fischer B, Sayk F (2018) Med Klin Intensivmed Notfallmed 113:305CrossRefGoogle Scholar
  13. 13.
    Demirel A, Kalkan A, Metin DD, Akkoc I, Sut R, Yeniocak S (2018) Am Med J 17:57Google Scholar
  14. 14.
    Smolinske S, Hoffman RS, Villeneuve E, Hoegberg LCG, Gosselin S (2018) Clin Toxicol. CrossRefGoogle Scholar
  15. 15.
    Eyer F, Pfab R, Felgenhauer N, Strubel T, Saugel B, Zilker T (2011) Clin Toxicol 49:846CrossRefGoogle Scholar
  16. 16.
    Toxicology ACM (2016) J Med Toxicol 12:416CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Jozef Klučka
    • 1
  • Tomáš Juřenčák
    • 2
  • Martina Kosinová
    • 1
  • Štourač Petr
    • 1
    Email author
  • Milan Kratochvíl
    • 1
  • Yvona Sedláčková
    • 1
  • Navrátil Tomáš
    • 3
  • Daniela Pelclová
    • 4
  • Petr Jabandžiev
    • 2
  1. 1.Department of Paediatric Anaesthesiology and Intensive Care Medicine, University Hospital Brno, Faculty of MedicineMasaryk University BrnoBrnoCzech Republic
  2. 2.Department of Paediatric, University Hospital Brno, Faculty of MedicineMasaryk University BrnoBrnoCzech Republic
  3. 3.J. Heyrovsky Institute of Physical Chemistry of the Academy of Sciences of the Czech RepublicPrague 8Czech Republic
  4. 4.Toxicological Information Centre, Department of Occupational Medicine, First Faculty of MedicineCharles University and General University Hospital PraguePragueCzech Republic

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