Modular syntheses of 1,4,5-trisubstituted 1,2,3-triazoles by a one-pot three-step procedure: toward bio-inspired monomers

  • Annie Praud-Tabariès
  • Olivier Bottzeck
  • Yves BlacheEmail author
Original Paper


Synthesis of 1,4,5-trisubstituted 1H-1,2,3-triazoles is reported by means of a transition metal-catalyzed arylation of 1-substituted-4-(2-bromoethyl)triazoles. The process which consists of one-pot three-step procedure allows a direct access to 1,5-disubstituted-4-(2-hydroxyethyl)triazoles and is suitable as an alternative methodology in the preparation of highly substituted triazoles in view of polymer chemistry.

Graphical abstract


1,2,3-Triazole Pd-catalyzed arylation Heck reaction Absorption click chemistry 



This research was supported by the University of Toulon and did not receive any specific grant from other funding agencies (public, or private).


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Université de Toulon, “MAPIEM”ToulonFrance

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