Novel cobalt-valine catalyzed O-arylation of phenols with electron deficient aryl iodides
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A Novel cobalt-catalyzed O-arylation of phenols with electron deficient aryl iodides is described. The reaction employs cheap and easy-to-handle cobalt acetate tetrahydrate as the catalyst precursor and naturally occurring l-valine as the ligand without the use of any transmetallating or reducing agents. The new protocol offers a wide scope for a variety of phenols towards O-arylation with moderate to excellent yields with electron deficient aryl iodides.
KeywordsCobalt catalysis C–O coupling Etherification Valine Reducing agent
SMU thanks the University Grants Commission (UGC-New Delhi), India for a research fellowship. SS and NAH thank the Council of Scientific and Industrial Research (CSIR-New Delhi), India for their research fellowships. GA thanks the Kerala State Council for Science Technology and Environment (KSCSTE), Trivandrum, India for a research grant (Order no. 341/2013/KSCSTE dated 15.03.2013). We greatly acknowledge the support from Department of Science and Technology (DST-New Delhi) under the DST-PURSE programme.