Monatshefte für Chemie - Chemical Monthly

, Volume 150, Issue 2, pp 339–346 | Cite as

Novel cobalt-valine catalyzed O-arylation of phenols with electron deficient aryl iodides

  • Sankuviruthiyil M. Ujwaldev
  • Salim Saranya
  • Nissy Ann Harry
  • Gopinathan AnilkumarEmail author
Original Paper


A Novel cobalt-catalyzed O-arylation of phenols with electron deficient aryl iodides is described. The reaction employs cheap and easy-to-handle cobalt acetate tetrahydrate as the catalyst precursor and naturally occurring l-valine as the ligand without the use of any transmetallating or reducing agents. The new protocol offers a wide scope for a variety of phenols towards O-arylation with moderate to excellent yields with electron deficient aryl iodides.

Graphical abstract


Cobalt catalysis C–O coupling Etherification Valine Reducing agent 



SMU thanks the University Grants Commission (UGC-New Delhi), India for a research fellowship. SS and NAH thank the Council of Scientific and Industrial Research (CSIR-New Delhi), India for their research fellowships. GA thanks the Kerala State Council for Science Technology and Environment (KSCSTE), Trivandrum, India for a research grant (Order no. 341/2013/KSCSTE dated 15.03.2013). We greatly acknowledge the support from Department of Science and Technology (DST-New Delhi) under the DST-PURSE programme.

Supplementary material

706_2018_2324_MOESM1_ESM.docx (17.1 mb)
Supplementary material 1 (DOCX 17529 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Chemical SciencesMahatma Gandhi UniversityKottayamIndia

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