Monatshefte für Chemie - Chemical Monthly

, Volume 150, Issue 2, pp 303–307 | Cite as

A green one-pot synthesis of α-amino nitrile derivatives via Strecker reaction in deep eutectic solvents

  • Abdolaziz Bahrani
  • Zahed Karimi-JaberiEmail author
Original Paper


In this work, the synergic effect of choline chloride/urea as a deep eutectic solvent was investigated in the three-component Strecker reaction for the synthesis of α-amino nitriles that contain a thiazole moiety. A simple separation, easy to set up, eco-friendly, and short time for purification of products in high yields without using chromatography are the advantages of this catalytic protocol.

Graphical abstract


Multicomponent reactions Green chemistry 2-Aminobenzothiazole 



We gratefully acknowledge financial support from the Islamic Azad University.

Supplementary material

706_2018_2313_MOESM1_ESM.docx (1.7 mb)
Supplementary material 1 (DOCX 1757 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemistry, Firoozabad BranchIslamic Azad UniversityFiroozabadIran

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