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Monatshefte für Chemie - Chemical Monthly

, Volume 150, Issue 2, pp 283–294 | Cite as

Synthesis approach and biological activity evaluation of a series of 1,3,2-oxazaphosphole-2-oxides against inflammation and nociception

  • Wafaa M. AbdouEmail author
  • Eman SabryEmail author
  • Abeer A. Shaddy
Original Paper
  • 68 Downloads

Abstract

In the present work, we synthesized a series of substituted benzoxazaphosphole-2-oxides in high yields (68–84%). The approach involved the preparation of oxazaphospholo-2-oxide monochloride, which is the key substrate, followed by its treatment with amino-, hydroxyl-, and thiolocompounds under mild conditions to afford the corresponding cyclophosphamide, cyclophosphamidate, and cyclophosphathioamidate groups as target products. Lipophilicity prediction and in vivo antinociceptive and antiinflammatory properties of new molecules were determined. Out of 14 tested compounds, the most hydrophobic compounds were found to be also of the highest antinociceptive and the antiinflammatory effects compared with reference drugs ibuprofen and indomethacin. The pharmacological results also showed that three candidates from the cyclophosphamide group are more active as antiinflammatory agents than the reference drug at all the successive time intervals.

Graphical abstract

Keywords

Antiinflammation Antinociception Lipophilicity measurement Substituted 1,3,2-oxazaphosphole-2-oxides synthesis 

Notes

Acknowledgements

Authors like to thank the National Research Centre, Dokki, Cairo Egypt (project # 10010340) for financial support. Authors also like to thank the Central Lab, School of Pharmacy, Alexandria University, Egypt for taking care of biological assays.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Chemical Industries Research DivisionNational Research CentreDokkiEgypt

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