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Monatshefte für Chemie - Chemical Monthly

, Volume 150, Issue 2, pp 139–161 | Cite as

Synthesis of azulenic compounds substituted in the 1-position with heterocycles

  • Alexandru C. Razus
  • Liviu BirzanEmail author
Review
  • 61 Downloads

Abstract

The review proposes an overview of the important general routes for the achievement of 1-heteroarylazulenes using both azulene substitution by heterocycles and azulenic cyclic construction pathways. With strong electrophilic heterocyclic derivatives, the electrophilic substitution takes place while concerted route is adopted for medium and low reactive heterocyclic substrates. Particular attention has been paid to the heterocycles construction from the functional groups attached to azulenic 1-position.

Graphical abstract

Keywords

Azulene Heterocycle 1-Heteroarylazulene Electrophilic substitution Coupling reactions 

Notes

Acknowledgements

A. C. R. is thankful to the Humboldt Foundation, and special gratitude is due to Prof. Klaus Hafner for helpful suggestions and discussions during and after the scholarship of the author.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Romanian Academy, Institute of Organic ChemistryBucharestRomania

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