MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus
Polymorphisms in the microsomal triglyceride transfer protein (MTTP) gene were genotyped in individuals who were chronically infected with hepatitis C virus (HCV). In the 236 patients, the frequencies of risk alleles of the -164T/C (rs1800804), -400A/T (rs1800803) and H297Q (rs2306985) polymorphisms were 0.30, 0.41 and 0.50, respectively. A significant association between the risk alleles of the -164T/C and -400A/T polymorphisms combined with HCV genotype 3 infection and the occurrence of steatosis was detected (p = 0.004 and p = 0.032), suggesting that a combination of host and viral factors can potentially be used to predict hepatic steatosis.
This study was funded by the Sao Paulo Research Foundation (FAPESP) via grant #2016/19690-5.
Compliance with ethical standards
Conflict of interest
All authors declare no conflict of interest.
This research received the approval of the Ethics Committee for Research Projects Analysis (CAPPesq) of the Clinical Hospital, School of Medicine, University of Sao Paulo, Brazil, #1.645.384/2016, and was performed according to the Declaration of Helsinki. All data were analyzed anonymously.
The participants involved in this research signed an informed consent statement.
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